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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Machine-learned analysis of global and glial/opioid intersection–related DNA methylation in patients with persistent pain after breast cancer surgery

Fig. 4

Data structure found in the input space of d = 14 CpG methylations acquired from patients with either persistent (n = 70) or non-persistent (n = 70) pain after breast cancer surgery. The data structure has been obtained by means of data projection principal component analysis on the non-normalized data as suggested by the results of the PC-corr analysis [50]. The PCA plot associated to this analysis shows the sample separation in the first and second component (PC1 versus PC2) yielded the best explained variance for non-normalized, non-centered PCA. The marginal distribution plots show the segregation of the pain phenotype groups along the first principal component. The figure has been created using the R software package (version 3.4.4 for Linux; http://CRAN.R-project.org/ [40]) and the library “ggplot2” (https://cran.r-project.org/package=ggplot2 [65])

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