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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Machine-learned analysis of global and glial/opioid intersection–related DNA methylation in patients with persistent pain after breast cancer surgery

Fig. 1

Methylation at d = 14 CpG sites located in the OPRM1 or TLR4 genes or in the retrotransposon LINE1 (raw data, for numerical results, see also Table 1). a Raw data are shown separately for group membership to the persistent pain or non-persistent pain phenotype groups. The widths of the boxes are proportional to the respective numbers of subjects per group. The quartiles and medians (solid horizontal line within the box) are used to construct a “box and whisker” plot. The whiskers add 1.5 times the interquartile range (IQR) to the 75th percentile or subtract 1.5 times the IQR from the 25th percentile and are expected to include 99.3% of the data if normally distributed. The notches indicate the confidence interval around the median based on median ± 1.57 ∙ IQR/n0.5. b Results of Wilcoxon tests for group differences in the methylation status at each CpG sites. The bars indicate the obtained p values, rescaled as –log10(p). Uncorrected and corrected significance thresholds are shown as horizontal lines. A significant difference is found when the bar exceeds the line. The figure has been created using the R software package (version 3.4.4 for Linux; http://CRAN.R-project.org/ [40])

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