Table 4 Uniplex and multiplex logistic regression model for biomarker performance using an increased number of biopsies (≥ 4 four biopsies)

CG

Coefficient

AUC

p value

C-3 Max

0.0511

− 1.5444

1.052 (1.002–1.106)

0.611

0.042

C-7 Max

0.0419

− 1.7637

1.043 (1.005–1.083)

0.626

0.028

C-10 Max

0.0924

− 1.8233

1.097 (1.021–1.179)

0.667

0.012

C-10 Mean

0.0992

− 1.6387

1.104 (1.012–1.205)

0.625

0.026

E-1 Mean

0.0937

− 3.6503

1.098 (1.043–1.156)

0.712

0.001

E-1 Max

0.0769

− 3.349

1.080 (1.034–1.128)

0.722

0.001

E-2 Mean

0.1019

− 3.3565

1.107 (1.048–1.170)

0.741

0.001

E-2 Max

0.0807

− 2.9841

1.084 (1.036–1.134)

0.722

0.001

E-3 Mean

0.0667

− 3.1724

1.069 (1.028–1.112)

0.679

0.001

E-3 Max

0.0447

− 2.4064

1.046 (1.017–1.076)

0.660

0.002

E-4 Mean

0.0416

− 3.1792

1.042 (1.004–1.082)

0.654

0.030

E-5 Max

0.0648

− 3.988

1.067 (1.022–1.114)

0.714

0.003

E-5 Mean

0.0692

− 3.8805

1.072 (1.022–1.124)

0.702

0.004

E-6 Max

0.092

− 3.4551

1.096 (1.038–1.158)

0.690

0.001

E-6 Mean

0.1015

− 3.3915

1.107 (1.037–1.181)

0.694

0.002

F-1 Min

-0.0459

3.2474

0.955 (0.915–0.997)

0.623

0.038

F-2 Min

-0.0492

3.2673

0.952 (0.909–0.998)

0.610

0.039

F-3 Min

-0.0597

3.2681

0.942 (0.898–0.988)

0.645

0.015

F-3 Mean

-0.0584

3.5090

0.943 (0.893–0.997)

0.628

0.038

F-4 Min

-0.051

3.6573

0.950 (0.912–0.990)

0.638

0.015

N-2 Mean

-0.1211

4.3103

0.886 (0.764–1.027)

0.586

0.049

P-2 Max

0.0879

− 1.7649

1.092 (1.011–1.179)

0.600

0.025

P-2 Mean

0.1119

− 1.9961

1.118 (1.002–1.248)

0.607

0.045

P-3 Mean

0.1868

− 2.669

1.205 (1.055–1.377)

0.662

0.006

P-3 Max

0.1278

− 2.049

1.136 (1.033–1.250)

0.661

0.009

P-4 Mean

0.0382

− 1.8555

1.039 (1.002–1.077)

0.618

0.038

P-5 Mean

0.1194

− 2.4529

1.127 (1.029–1.234)

0.655

0.010

P-5 Max

0.0961

− 2.1926

1.101 (1.022–1.186)

0.659

0.011

P-6 Mean

0.0694

− 1.6402

1.072 (1.004–1.144)

0.617

0.036

S-1 Max

0.0718

− 1.7891

1.074 (1.014–1.138)

0.630

0.014

S-2 Max

0.0717

− 2.3864

1.074 (1.020–1.132)

0.651

0.007

S-4 Max

0.0741

− 1.6883

1.077 (1.007–1.152)

0.626

0.030

S-5 Mean

0.1648

− 3.1627

1.179 (1.074–1.294)

0.706

0.001

S-5 Max

0.1023

− 2.2471

1.108 (1.040–1.180)

0.681

0.001

0.774

0.0004

C10 Max

− 0.0176

− 1.9828

0.983 (0.890–1.085)

E-2 Mean

0.084

− 1.9828

1.088 (1.018–1.162)

F-3 Min

− 0.031

− 1.9828

0.969 (0.913–1.030)

N-2 Mean

− 0.0488

− 1.9828

0.952 (0.797–1.139)

P-3 Mean

0.0339

− 1.9828

1.034 (0.865–1.238)

S-5 Mean

0.1049

− 1.9828

1.111 (0.977–1.263)