Validation of an epigenetic field of susceptibility to detect significant prostate cancer from non-tumor biopsies

Clinical Epigenetics

Table 3 Multiplex logistic regression model to detect cancer using panel markers and clinical features (Age, PSA)

Combined	Coefficient	Constant	O.R. (95% CI)
Age	0.0886	− 0.9658	1.093 (0.996–1.198)
LPSA	− 2.2394	− 0.9658	0.107 (0.027–0.416)
C-10 Max	0.0536	− 0.9658	1.055 (0.932–1.194)
E-1 Max	0.0588	− 0.9658	1.061 (1.001–1.124)
F-3 Min	− 0.0173	− 0.9658	0.983 (0.920–1.049)
N-2 Min	− 0.1285	− 0.9658	0.879 (0.752–1.028)
P-5 Max	0.0497	− 0.9658	1.051 (0.903–1.223)
S-2 Max	− 0.00503	− 0.9658	0.995 (0.906–1.093)

C, CAV1; E, EVX1; F, FGF1; N, NCR2; P, PLA2G16; S, SPAG4; Max, maximal methylation value between the two biopsies; Min, minimal methylation value between the two biopsies; LPSA, logPSA; O.R., odds ratio; AUC, area under the curve value. Number after each letter represents the CG position tested

ISSN: 1868-7083