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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression

Fig. 2

Increases in depressive symptom load negatively correlate with DNA methylation in a significant region identified on chromosome 15. The significantly differentially methylated region (row 2, “DMR”) was built using 5 of the 21 CpG probes available on the EPIC array (row 1, “EPIC”). The mean group methyl values are shown for low, mid, and high depressive symptom loads based on Edinburgh Postnatal Depression Scale (EPDS) total score (low = 0–4; mid = 5–12; high = 13 and greater). The threshold of 13 or greater for the high group was selected based on the validated cutoff score for English-speaking women in the postpartum time period shortly following birth [31]

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Clinical Epigenetics

ISSN: 1868-7083

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