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Table 3 Diagnostic impacts of methylation profiling

From: The central nervous system tumor methylation classifier changes neuro-oncology practice for challenging brain tumor diagnoses and directly impacts patient care

Category

N

%

Diagnostic effecte

Change in diagnosis

13

24

Resolution of differential diagnosis

17

31

Molecular refinement

16

29

Diagnostic validation

9

16

WHO grade changee

Upgrade

10

18

Downgrade

3

5

Assign grade

2

4

Unchanged

40

73

All molecular refinementse

Change in IDH mutation status

9

16

Final determination of an unclear IDH mutation status

23

42

Identification of molecular subtype

20

36

Determination of 1p/19q co-deletion status

6

11

  1. bn = 47
  2. en = 55