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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Combined genetic mutations and DNA-methylated genes as biomarkers for endometrial cancer detection from cervical scrapings

Fig. 3

Comparison of genetic mutations (PTEN and TP53) and aberrantly DNA-methylated genes (BHLHE22, CDO1, HAND2, and TBX5) in cervical scrapings. a The distribution and frequency of PTEN and TP53 gene mutations in non-endometrial cancer (non-EC), type I EC, and type II EC are shown. PTEN mutations were more frequently observed in type I EC. b Combination of DNA methylation and any genetic mutation in EC and non-EC. The absence of PTEN and TP53 mutations and no DNA methylation of any of the four candidate genes were seen in one of the 16 type II EC samples. This sample also revealed unique copy number instability (CNI)

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Clinical Epigenetics

ISSN: 1868-7083

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