Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome

Clinical Epigenetics

Table 4 Annotations for the nine overlapping CpGs for the cisplatin-based chemotherapy (CBCT) model and metabolic syndrome (MetS) model for the 2000 CpGs with the lowest unadjusted p values < 0.05

Cpg name	Gene^a	P^b CBCT model	P^b MetS model	Gene function	Disease/Trait association^d
cg25165017		< 0.001	0.001
cg27087650	BCL3	< 0.001	0.012	Contributes to the regulation of cell proliferation
cg10785263		< 0.001	0.020
cg17986793	MX1	< 0.001	0.022	Gene product, Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene
cg10587886	LMCD1-AS1	< 0.001	0.044	LMCD1 antisense RNA 1
cg18871648	ELMSAN1	< 0.001	0.050	ELM2 and Myb/SANT domain containing 1
cg07688244		< 0.001	0.098
cg14792781	GRHL1	< 0.001	0.127	This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development
cg25273039	NXPH1	< 0.001	0.165	The product protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons	Waist-to-hip ratio adjusted for body mass index, Obesity-related traits
cg19509829	ATP2A2	< 0.001	0.215	Product Belongs to a family of ATPase enzymes that helps control the level of positively charged calcium atoms (calcium ions) inside cells	Glucose homeostasis traits

^aGene UCSC gene name
^bP unadjusted p value
^cSelected from GeneToFunction database (human only) and Gene Cards disease associations

ISSN: 1868-7083