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Table 4 Annotations for the nine overlapping CpGs for the cisplatin-based chemotherapy (CBCT) model and metabolic syndrome (MetS) model for the 2000 CpGs with the lowest unadjusted p values < 0.05

From: Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome

Cpg nameGeneaPb CBCT modelPb MetS modelGene functionDisease/Trait associationd
cg25165017 < 0.0010.001  
cg27087650BCL3< 0.0010.012Contributes to the regulation of cell proliferation 
cg10785263 < 0.0010.020  
cg17986793MX1< 0.0010.022Gene product, Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene 
cg10587886LMCD1-AS1< 0.0010.044LMCD1 antisense RNA 1 
cg18871648ELMSAN1< 0.0010.050ELM2 and Myb/SANT domain containing 1 
cg07688244 < 0.0010.098  
cg14792781GRHL1< 0.0010.127This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development 
cg25273039NXPH1< 0.0010.165The product protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axonsWaist-to-hip ratio adjusted for body mass index, Obesity-related traits
cg19509829ATP2A2< 0.0010.215Product Belongs to a family of ATPase enzymes that helps control the level of positively charged calcium atoms (calcium ions) inside cellsGlucose homeostasis traits
  1. aGene UCSC gene name
  2. bP unadjusted p value
  3. cSelected from GeneToFunction database (human only) and Gene Cards disease associations