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Table 3 The 15 CpG sites with lowest unadjusted p values for associations between DNA methylation (DNAm) and metabolic syndrome (MetS)

From: Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome

CpG nameGeneaPbGene functionDisease/Trait associationc
cg01562302SLC7A74.37E-06Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids 
cg06500161ABCG16.50E-06Involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell typesType 1 diabetes
cg05489343COLEC121.26E-05Scavenger receptor associated with host defense, C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domainsObesity-related traits
cg07203167NCF2/SMG71.57E-05Required for activation of the latent NADPH oxidaseInsulin resistance
cg23064281 2.44E-05  
cg22084453 2.51E-05  
cg09209794TMEM63A3.15E-05Acts as an osmosensitive calcium-permeable cation channel 
cg16007266NLRC53.31E-05Plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathwaysHDL cholesterol
cg09120938CHFR3.67E-05Regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis, belongs to DNA damage pathway 
cg02255098BCAM3.71E-05A receptor for the extracellular matrix protein, laminin.Waist-to-hip circumference ratio
cg22926824AGAP14.18E-05Direct regulator of the adaptor-related protein complex 3 on endosomesCardiovascular disease in hypertension (calcium channel blocker interaction)
cg22003124 4.21E-05  
cg16307144DPF14.55E-05Gene Ontology (GO) annotations related to this gene include nucleic acid binding 
  1. aGene UCSC gene name
  2. bP value unadjusted p value
  3. cSelected from GeneToFunction database (human only) and Gene Cards disease associations