Table 3 The 15 CpG sites with lowest unadjusted p values for associations between DNA methylation (DNAm) and metabolic syndrome (MetS)

cg01562302

SLC7A7

4.37E-06

Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids

cg06500161

ABCG1

6.50E-06

Involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types

Type 1 diabetes

cg05489343

COLEC12

1.26E-05

Scavenger receptor associated with host defense, C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains

Obesity-related traits

cg07203167

NCF2/SMG7

1.57E-05

Required for activation of the latent NADPH oxidase

Insulin resistance

cg23064281

2.44E-05

cg22084453

2.51E-05

cg09209794

TMEM63A

3.15E-05

Acts as an osmosensitive calcium-permeable cation channel

cg23167087

TTC18/CFAP70

3.20E-05

cg16007266

NLRC5

3.31E-05

Plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways

HDL cholesterol

cg14810357

AC064875.2

3.49E-05

cg09120938

CHFR

3.67E-05

Regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis, belongs to DNA damage pathway

cg02255098

BCAM

3.71E-05

A receptor for the extracellular matrix protein, laminin.

Waist-to-hip circumference ratio

cg22926824

AGAP1

4.18E-05

Direct regulator of the adaptor-related protein complex 3 on endosomes

Cardiovascular disease in hypertension (calcium channel blocker interaction)

cg22003124

4.21E-05

cg16307144

DPF1

4.55E-05

Gene Ontology (GO) annotations related to this gene include nucleic acid binding