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Table 2 Annotations for the 35 FDR significant CpGs (adjusted p values < 0.05) for cisplatin-based chemotherapy (CBCT) model

From: Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome

CpG nameGene nameaFDRbBonfcFunction of the gene productDisease/Trait associationd
cg07677157RP11-221N13.49.56E-159.56E-15  
cg08057120 7.78E-121.56E-11  
cg26408927CACNA1D2.26E-106.79E-10Mediate the entry of calcium ions into excitable cells. Involved in a variety of calcium-dependent processes. Regulates intracellular processes such as contraction, secretion, neurotransmission and other gene expressionSinoatrial node dysfunction and deafness. Hypertension. Body mass index. Insulin resistance/response. Systolic blood pressure. Diastolic blood pressure. Visceral adipose tissue/subcutaneous adipose tissue ratio. Type 2 diabetes
cg27487222 7.37E-072.95E-06  
cg11031221LINC005111.56E-067.78E-06A long non-protein coding RNA, involved in the regulation of gene expression during tumor progression 
cg22688137 6.01E-05< 0.001  
cg24833462AC023672.2< 0.001< 0.001  
cg20063141ONECUT2/
AC090340.1
< 0.0010.004This gene encodes a member of the one cut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain 
cg08889373ACOT7/RP1-202O8.30.0010.009Protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acidsType 2 diabetes. Atherosclerosis
cg14792781GRHL10.0020.016Is a transcription factor necessary during developmentCancer. Type 1 diabetes
cg14634473 0.0020.021  
cg21940081IMP40.0030.037Part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. Responsible for early cleavage steps of pre-18S ribosomal RNA processing 
cg03877706NCAM20.0030.041Belongs to the immunoglobulin superfamily. May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axonsObesity. Visceral fat
cg00303773TOM1L20.0050.070Participate in vesicular trafficking. Play a role in endosomal sortingBody mass. Type 2 diabetes
cg10113471 0.0050.069  
cg23304747PITPNM20.0080.123Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions 
cg14972510BAG40.0100.167Inhibits the chaperone activity of HSP70/HSC70. Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria 
cg26561082DIP2C0.0110.197The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous systemBlood metabolite levels
cg24869056HPS10.0120.235Play a role in organelle biogenesis associated with melanosomes, platelet dense granules and lysosomesObesity-related traits
cg14629524KDM3B0.0200.401Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code 
cg04156896MFSD2A0.0210.459Transmembrane protein and sodium-dependent lysophosphatidylcholine transporter involved in the establishment of the blood-brain barrier 
cg27367992ST6GAL10.0210.451Catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substratesType 2 diabetes
cg08343240AC008703.10.0240.573RNA gene 
cg27545041 0.0240.567An important paralog of this gene is INTS6 / RNA Gene and is affiliated with the non-coding RNA class 
cg04046944CACNA1S0.0250.614This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells 
cg06225648 0.0250.651  
cg12381697CCM20.0280.751  
cg13207339PARK20.0300.849A component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradationMetabolite levels. Body mass index. Aging
cg22345432PXN/
PXN-AS1
0.0330.972Involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion)/RNA Gene and is affiliated with the non-coding RNA class 
cg17158941C7orf50/AC073957.150.0401Chromosome 7 Open Reading Frame 50C-reactive protein levels or total cholesterol levels
cg03289031ZNF6290.0401  
cg26540402PRF10.0401Plays a key role in secretory granule-dependent cell death and in defense against virus infected or neoplastic cells 
cg16657582 0.0431  
cg21902759RAB40B0.0431Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins 
cg19377056ARHGAP390.0491  
  1. aUCSC gene name
  2. bFDR - CBCT False Discovery Rate significance (p < 0.05)
  3. cBonf - CBCT Bonferroni significance (p < 0.05)
  4. dSelected from GeneToFunction database (human only) and Gene Cards disease associations