From: Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome
CpG name | Gene namea | FDRb | Bonfc | Function of the gene product | Disease/Trait associationd |
---|---|---|---|---|---|
cg07677157 | RP11-221N13.4 | 9.56E-15 | 9.56E-15 | Â | Â |
cg08057120 | Â | 7.78E-12 | 1.56E-11 | Â | Â |
cg26408927 | CACNA1D | 2.26E-10 | 6.79E-10 | Mediate the entry of calcium ions into excitable cells. Involved in a variety of calcium-dependent processes. Regulates intracellular processes such as contraction, secretion, neurotransmission and other gene expression | Sinoatrial node dysfunction and deafness. Hypertension. Body mass index. Insulin resistance/response. Systolic blood pressure. Diastolic blood pressure. Visceral adipose tissue/subcutaneous adipose tissue ratio. Type 2 diabetes |
cg27487222 | Â | 7.37E-07 | 2.95E-06 | Â | Â |
cg11031221 | LINC00511 | 1.56E-06 | 7.78E-06 | A long non-protein coding RNA, involved in the regulation of gene expression during tumor progression | Â |
cg22688137 |  | 6.01E-05 | < 0.001 |  |  |
cg24833462 | AC023672.2 | < 0.001 | < 0.001 |  |  |
cg20063141 | ONECUT2/ AC090340.1 | < 0.001 | 0.004 | This gene encodes a member of the one cut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain |  |
cg08889373 | ACOT7/RP1-202O8.3 | 0.001 | 0.009 | Protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids | Type 2 diabetes. Atherosclerosis |
cg14792781 | GRHL1 | 0.002 | 0.016 | Is a transcription factor necessary during development | Cancer. Type 1 diabetes |
cg14634473 | Â | 0.002 | 0.021 | Â | Â |
cg21940081 | IMP4 | 0.003 | 0.037 | Part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. Responsible for early cleavage steps of pre-18S ribosomal RNA processing | Â |
cg03877706 | NCAM2 | 0.003 | 0.041 | Belongs to the immunoglobulin superfamily. May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons | Obesity. Visceral fat |
cg00303773 | TOM1L2 | 0.005 | 0.070 | Participate in vesicular trafficking. Play a role in endosomal sorting | Body mass. Type 2 diabetes |
cg10113471 | Â | 0.005 | 0.069 | Â | Â |
cg23304747 | PITPNM2 | 0.008 | 0.123 | Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions | Â |
cg14972510 | BAG4 | 0.010 | 0.167 | Inhibits the chaperone activity of HSP70/HSC70. Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria | Â |
cg26561082 | DIP2C | 0.011 | 0.197 | The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system | Blood metabolite levels |
cg24869056 | HPS1 | 0.012 | 0.235 | Play a role in organelle biogenesis associated with melanosomes, platelet dense granules and lysosomes | Obesity-related traits |
cg14629524 | KDM3B | 0.020 | 0.401 | Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code | Â |
cg04156896 | MFSD2A | 0.021 | 0.459 | Transmembrane protein and sodium-dependent lysophosphatidylcholine transporter involved in the establishment of the blood-brain barrier | Â |
cg27367992 | ST6GAL1 | 0.021 | 0.451 | Catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates | Type 2 diabetes |
cg08343240 | AC008703.1 | 0.024 | 0.573 | RNA gene | Â |
cg27545041 | Â | 0.024 | 0.567 | An important paralog of this gene is INTS6 / RNA Gene and is affiliated with the non-coding RNA class | Â |
cg04046944 | CACNA1S | 0.025 | 0.614 | This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells | Â |
cg06225648 | Â | 0.025 | 0.651 | Â | Â |
cg12381697 | CCM2 | 0.028 | 0.751 | Â | Â |
cg13207339 | PARK2 | 0.030 | 0.849 | A component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation | Metabolite levels. Body mass index. Aging |
cg22345432 | PXN/ PXN-AS1 | 0.033 | 0.972 | Involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion)/RNA Gene and is affiliated with the non-coding RNA class | Â |
cg17158941 | C7orf50/AC073957.15 | 0.040 | 1 | Chromosome 7 Open Reading Frame 50 | C-reactive protein levels or total cholesterol levels |
cg03289031 | ZNF629 | 0.040 | 1 | Â | Â |
cg26540402 | PRF1 | 0.040 | 1 | Plays a key role in secretory granule-dependent cell death and in defense against virus infected or neoplastic cells | Â |
cg16657582 | Â | 0.043 | 1 | Â | Â |
cg21902759 | RAB40B | 0.043 | 1 | Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | Â |
cg19377056 | ARHGAP39 | 0.049 | 1 | Â | Â |