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Table 1 IC50 values, or percentage of inhibition at 200 μM, of MC4040 and MC4041 against a panel of methyltransferases

From: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype

CompoundIC50, μMa or % inhibition at 200 μM
EZH2EZH1G9aPRMT1DNMT1
MC40404.0642.7NAbNANA
MC40411.0610.6NA11.9%NA
SAH34.7    
GSK1260.009    
TAZc<0.005    
  1. aPerformed in a 10-dose IC50 mode with 2-fold serial dilution starting from 200 μM. bNA, not active. cTAZ, tazemetostat