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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype

Fig. 2

a MC4040 (carbon atoms in black) docked conformation into PCR2. Only surface (blue) and names of residues within 5 Å are displayed. Close contact surfaces with the pyridone moiety are coloured in pink. Close contact surfaces with the pyrrole-3-carboxamide central group are coloured in magenta and contact surfaces with the piperidine heterocycle are coloured in yellow. Residue numbering is taken from the 6b3w complex. b MC4041 (carbon atoms in dark grey) docked conformation into PCR2. Only surface (blue) and names of residues within 5 Å are displayed. Close contact surfaces with the pyridone moiety are coloured in pink. Close contact surfaces with the pyrrole-3-carboxamide central group are coloured in magenta and contact surfaces with the piperidine heterocycle are coloured in orange. Residue numbering are taken from the 6b3w complex

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