Fig. 2

a MC4040 (carbon atoms in black) docked conformation into PCR2. Only surface (blue) and names of residues within 5 Å are displayed. Close contact surfaces with the pyridone moiety are coloured in pink. Close contact surfaces with the pyrrole-3-carboxamide central group are coloured in magenta and contact surfaces with the piperidine heterocycle are coloured in yellow. Residue numbering is taken from the 6b3w complex. b MC4041 (carbon atoms in dark grey) docked conformation into PCR2. Only surface (blue) and names of residues within 5 Å are displayed. Close contact surfaces with the pyridone moiety are coloured in pink. Close contact surfaces with the pyrrole-3-carboxamide central group are coloured in magenta and contact surfaces with the piperidine heterocycle are coloured in orange. Residue numbering are taken from the 6b3w complex