Table 4 GO analysis of identified DMR genes

BP

Regulation of heart morphogenesis

SIX1 WNT3A, TBX1, SOX9

5.63e-06

0.0050

Glutamate receptor signaling pathway

MINK1, GRIN3B, SHANK1, MAPK8IP2

0.0001

0.0074

Organ morphogenesis

SIX1, LEFTY1, SIX6, TBX1, SOX9, AXIN2, DUOX2, UNCX, WNT3A, TLX1, F7, MYO15A, FOXL1, KIF26B

0.0001

0.0074

Nervous system development

MINK1, SLC8A3, SOX9, CACNA1H, STMN3, UNCX, TLX1, SEPP1, FOXL1, MAPK8IP2, FOXD2, RTN1, SIX1, TACC2, TBX1, SHANK1, MNX1, DUOX2, SALL3, WNT3A, BRSK2, CRMP1, PURA

3.20e-05

0.0074

Anatomical structure morphogenesis

MINK1, LEFTY1, SIX6, SOX9, SHROOM1, CACNA1H, UNCX, TLX1, MYO15A, FOXL1 MAPK8IP2, FOXD2, KIF26B, RSG1, SIX1, TBX1, SHANK1, MNX1, AXIN2, DUOX2, SALL3, ECE1, WNT3A, BRSK2, F7, CRMP1

2.06e-05

0.0074

Central nervous system development

SIX1, SLC8A3, TACC2, TBX1, MNX1, SOX9, DUOX2, UNCX, SALL3, WNT3A, TLX1, SEPP1, FOXL1

8.41e-05

0.0074

Ear development

DUOX2, SIX1, ECE1, WNT3A, MYO15A, TBX1, SOX9

6.29e-05

0.0074

System development

MINK1, LEFTY1, SIX6, SOX9, CACNA1H, TLX1, AHSP, SEPP1, RTN1, SIX1, ZNF354A, CBFA2T3, TACC2, SHANK1, MNX1, AXIN2, SALL3, ECE1, WNT3A, SLC8A3, STMN3, UNCX, MYO15A, FOXL1, MAPK8IP2, KIF26B, FOXD2, TBX1, DUOX2, HLA-DOA, BRSK2, CRMP1, F7, PURA

0.0002

0.0084

Thyroid gland development

DUOX2, SIX1, TBX1

0.0002

0.0084

Otic vesicle development

SIX1, TBX1, SOX9

0.0002

0.0084

Inner ear morphogenesis

SIX1, WNT3A, MYO15A, TBX1, SOX9

0.0002

0.0084

Inner ear development

DUOX2, SIX1, WNT3A, MYO15A, TBX1, SOX9

0.0002

0.0084

Regulation of ion transport

KCNA5, MINK1, DPP6, GRIN3B, SHANK1, MAPK8IP2, BEST1

0.0006

0.0133

MF

Scaffold protein binding

KCNA5, SHANK1, CACNA1H

0.0001

0.0143

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

PURA, FOXL1, SOX9, FOXD2, NFIX

0.0002

0.0143

Sequence-specific DNA binding transcription factor activity

SIX1, ZNF354A, CBFA2T3, SIX6, TBX1, MNX1, SOX9, UNCX, TLX1, PURA, FOXL1, FOXD2, NFIX

0.0019

0.00388