Epigenome-wide base-resolution profiling of DNA methylation in chorionic villi of fetuses with Down syndrome by methyl-capture sequencing

Table 1 Distribution of DMCs on chromosome

chr.	Size (Mb)	Hypermethlyated DMCs in DS			Hypomethylated DMCs in DS			Magnification of hypermethylated DMCs to hypomethylated DMCs	Magnification of hypermethylated DMCs to hypomethylated DMCs based on chromosome size
chr.	Size (Mb)	n	DMCs for each chromosome of total DMCs (%)	DMCs based on chromosome size (%)	n	DMCs for each chromosome in total DMCs (%)	DMCs based on chromosome size (%)
1	248.96	399	9.4	1.6	15	8.4	0.1	26.6	0.11
2	242.19	290	6.8	1.2	11	6.2	0.0	26.4	0.11
3	198.3	121	2.8	0.6	6	3.4	0.0	20.2	0.10
4	190.22	145	3.4	0.8	9	5.1	0.0	16.1	0.08
5	181.54	218	5.1	1.2	11	6.2	0.1	19.8	0.11
6	170.81	152	3.6	0.9	7	3.9	0.0	21.7	0.13
7	159.35	246	5.8	1.5	14	7.9	0.1	17.6	0.11
8	145.14	289	6.8	2.0	4	2.2	0.0	72.3	0.50*
9	138.4	93	2.2	0.7	7	3.9	0.1	13.3	0.10
10	133.8	217	5.1	1.6	7	3.9	0.1	31.0	0.23
11	135.09	259	6.1	1.9	16	9.0	0.1	16.2	0.12
12	133.28	167	3.9	1.3	9	5.1	0.1	18.6	0.14
13	114.36	99	2.3	0.9	4	2.2	0.0	24.8	0.22
14	107.04	148	3.5	1.4	3	1.7	0.0	49.3	0.46
15	101.99	156	3.7	1.5	4	2.2	0.0	39.0	0.38
16	90.34	179	4.2	2.0	13	7.3	0.1	13.8	0.15
17	83.26	182	4.3	2.2	9	5.1	0.1	20.2	0.24
18	80.37	93	2.2	1.2	4	2.2	0.0	23.3	0.29
19	58.62	476	11.2	8.1	15	8.4	0.3	31.7	0.54*
20	64.44	133	3.1	2.1	2	1.1	0.0	66.5	1.03*
21	46.71	60	1.4	1.3	2	1.1	0.0	30.0	0.64*
22	50.82	139	3.3	2.7	6	3.4	0.1	23.2	0.46
Total		4,261	100.0		178	100.0

Chr. chromosome, DMCs differentially methylated CpG sites, DS Down syndrome, Mb megabases, n number
*The proportional increase of hypermethylated DMCs to hypomethylated DMCs is 0.5 or more, depending on the chromosome size. It means that these chromosomes were more enriched with hypermethylated CpG sites.

ISSN: 1868-7083