Table 3 Differentially methylated, hydroxymethylated, and unmodified regions in the middle temporal gyrus
From: Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
Gene | Position | Gene feature | n | p value | Šidák P | Average Δ% (range Δ%) |
|---|---|---|---|---|---|---|
5mC | ||||||
OXT | chr20:3051954-3052484 | TSS; Intron; 5′UTR; CDS | 10 (0 up; 10 down) | 1.43E−09 | 1.07E−06 | − 3.76 (− 6.94:− 0.43) |
5hmC | ||||||
CHRNB1 | chr17:7348322-7348439 | TSS; Exon; 5′UTR | 5 (5 up; 0 down) | 2.63E−07 | 4.01E−04 | 1.46 (0.70:1.96) |
UC | ||||||
ACTR3C; LRRC61 | chr7:150019955-150020946 | TSS; Intron; Exon; 5′UTR | 17 (1 up; 16 down) | 3.54E−12 | 1.42E−09 | − 0.57 (− 1.34:0.02) |
RHBDF2 | chr17:74475240-74475403 | Intron; CDS | 5 (0 up; 5 down) | 1.99E−09 | 4.85E−06 | − 3.45 (− 4.71:− 1.42) |
TMC8 | chr17:76128522-76128907 | Intron; CDS | 8 (0 up; 8 down) | 3.29E−09 | 3.39E−06 | − 1.26 (− 2.84:− 0.26) |
ASPG | chr14:104551867-104552210 | TSS; Intron; 5′UTR; CDS | 5 (0 up; 5 down) | 1.00E−08 | 1.16E−05 | − 1.21 (− 2.49:− 0.28) |
PIEZO1 | chr16:88844969-88845205 | Intron | 3 (0 up; 3 down) | 1.87E−07 | 3.14E−04 | − 3.08 (− 3.76:− 2.32) |
VWA7 | chr6:31734106-31734472 | Intron; CDS | 10 (10 up; 0 down) | 2.04E−07 | 2.21E−04 | 3.39 (2.24:4.23) |
CLMAT3; SPARC | chr5:151066460-151066731 | Exon; TSS; 5′UTR | 6 (0 up; 6 down) | 5.21E−07 | 7.62E−04 | − 0.29 (− 0.64:0.21) |
KIAA1522 | chr1:33231070-33231314 | TSS; Exon; 5′UTR; Intron | 6 (0 up; 6 down) | 8.48E−07 | 1.38E−03 | − 1.85 (− 2.43:− 1.3) |
C3 | chr19:6713227-6713460 | Intron; CDS | 3 (1 up; 2 down) | 9.21E−07 | 1.57E−03 | − 1.20 (− 2.1:0.46) |
PRSS22 | chr16:2908157-2908246 | TSS; Exon; 5′UTR | 4 (0 up; 4 down) | 1.02E−06 | 4.52E−03 | − 1.56 (− 1.91:− 1.39) |
FRAT1 | chr10:99080756-99081017 | Exon | 3 (3 up; 0 down) | 1.50E−06 | 2.28E−03 | 2.34 (1.57:3.03) |