TY - JOUR AU - Lardenoije, Roy AU - Roubroeks, Janou A. Y. AU - Pishva, Ehsan AU - Leber, Markus AU - Wagner, Holger AU - Iatrou, Artemis AU - Smith, Adam R. AU - Smith, Rebecca G. AU - Eijssen, Lars M. T. AU - Kleineidam, Luca AU - Kawalia, Amit AU - Hoffmann, Per AU - Luck, Tobias AU - Riedel-Heller, Steffi AU - Jessen, Frank AU - Maier, Wolfgang AU - Wagner, Michael AU - Hurlemann, René AU - Kenis, Gunter AU - Ali, Muhammad AU - del Sol, Antonio AU - Mastroeni, Diego AU - Delvaux, Elaine AU - Coleman, Paul D. AU - Mill, Jonathan AU - Rutten, Bart P. F. AU - Lunnon, Katie AU - Ramirez, Alfredo AU - van den Hove, Daniël L. A. PY - 2019 DA - 2019/11/27 TI - Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood JO - Clinical Epigenetics SP - 164 VL - 11 IS - 1 AB - Late-onset Alzheimer’s disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present study investigated epigenome-wide patterns of DNA methylation (5-methylcytosine, 5mC) and hydroxymethylation (5-hydroxymethylcytosine, 5hmC), as well as the abundance of unmodified cytosine (UC), in relation to AD. SN - 1868-7083 UR - https://doi.org/10.1186/s13148-019-0755-5 DO - 10.1186/s13148-019-0755-5 ID - Lardenoije2019 ER -