Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity

Table 2 Association of BMI with epigenetic age acceleration in blood, VAT and liver

Variable	Blood			Visceral adipose tissue			Liver			Liver (obesity)
Variable	β	95% CI	p	β	95% CI	p	β	95% CI	p	β	95% CI	p
Chronological age	0.87	0.67–1.07	1.48 × 10⁻¹¹	0.66	0.53–0.80	2.63 × 10⁻¹³	0.71	0.62–0.81	< 2 × 10⁻¹⁶	0.80	0.65–0.95	7.56 × 10⁻¹³
BMI	0.16	− 0.04–0.36	0.12	0.15	0.04–0.28	0.03	0.16	0.07–0.25	5.6 × 10⁻⁴	0.24	0.04–0.45	0.02
Sex	− 3.11	− 6.54–0.33	0.08	2.89	0.59–5.20	0.02	− 1.47	− 4.07–1.13	0.26	− 0.28	− 4.12–3.56	0.88
Metabolic syndrome	0.47	− 2.75–3.69	0.77	1.42	− 0.74–3.58	0.19	-	-	-	-	-	-
Adjusted R²	0.64			0.67			0.82			0.78
Age acceleration	1.83			2.20			2.28			3.04

Estimates (β), 95% confidence intervals (95%CI), and p values (p) are from multivariate linear regression models of DNA methylation age acceleration adjusted by chronological age, body mass index (BMI), sex and metabolic syndrome. β represents the acceleration of epigenetic age in years by unit change of dependent variable. Age acceleration stands for the increase of epigenetic age in years for each 10-point increase in BMI

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