Skip to main content

Table 2 Association of BMI with epigenetic age acceleration in blood, VAT and liver

From: Body mass index is associated with epigenetic age acceleration in the visceral adipose tissue of subjects with severe obesity

VariableBlood Visceral adipose tissue Liver Liver (obesity)
β95% CIp β95% CIp β95% CIp β95% CIp
Chronological age0.870.67–1.071.48 × 10−11 0.660.53–0.802.63 × 10−13 0.710.62–0.81< 2 × 10−16 0.800.65–0.957.56 × 10−13
BMI0.16− 0.04–0.360.12 0.150.04–0.280.03 0.160.07–0.255.6 × 10−4 0.240.04–0.450.02
Sex− 3.11− 6.54–0.330.08 2.890.59–5.200.02 − 1.47− 4.07–1.130.26 − 0.28− 4.12–3.560.88
Metabolic syndrome0.47− 2.75–3.690.77 1.42− 0.74–3.580.19 --- ---
Adjusted R20.64   0.67   0.82   0.78  
Age acceleration1.83   2.20   2.28   3.04  
  1. Estimates (β), 95% confidence intervals (95%CI), and p values (p) are from multivariate linear regression models of DNA methylation age acceleration adjusted by chronological age, body mass index (BMI), sex and metabolic syndrome. β represents the acceleration of epigenetic age in years by unit change of dependent variable. Age acceleration stands for the increase of epigenetic age in years for each 10-point increase in BMI