The acceleration of epigenetic aging in VAT correlates with BMI in men. Panels a and d compare the distribution of DNA methylation (DNAm) age acceleration, defined as the residual from regressing DNAm age on chronological age, between men and women in blood (a) and visceral adipose tissue—VAT—(d). Boxplots represent the distribution of phenotype data with median (dark horizontal line) and interquartile range (box), and p stands for the p values obtained in Student’s t test for independent samples. The correlation between DNAm age acceleration and body mass index (BMI) in blood (b and c; red dashed line) and VAT (e and f, yellow dashed line) is shown separately in men and women. Residuals over zero (horizontal black line) stand for an acceleration of DNAm age, while r and p refer to Pearson correlation coefficients and p values, respectively. Blue and gray dots refer to men and women, respectively.