Table 2 DNAm-Alc and AUDIT score in the sub-sample with repeated DNAm-Alc measurements. Estimates of the effect of DNAm-Alc on AUDIT at a time point prior to AUDIT measurement (childhood, birth and pregnancy), at a time point cross-sectional to AUDIT (adolescence and midlife), and with the effect of prior and cross-sectional DNAm-Alc modelled simultaneously. see the ‘Methods’ for details

AUDIT at adolescence

~ Childhood

601

− 0.06

0.37

0.879

− 0.16

~ Adolescence

0.94

0.33

0.005

1.17

~ Childhood + adolescence

− 0.29, 0.99

0.37, 0.34

0.44, 0.004

1.11

AUDIT at adolescence

~ Birth

438

0.70

0.38

0.064

0.56

~ Adolescence

0.93

0.40

0.021

0.99

~ Birth + adolescence

0.56, 0.83

0.38, 0.41

0.138, 0.042

1.27

AUDIT at midlife

~ Pregnancy

518

0.15

0.26

0.557

− 0.13

~ Midlife

1.63

0.25

< 0.001

7.38

~ Pregnancy + midlife

− 0.14, 1.66

0.25, 0.26

0.574, < 0.001

7.25