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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Validation and characterisation of a DNA methylation alcohol biomarker across the life course

Fig. 3

Area under the curve for prediction of binary alcohol categories by DNAm-Alcs. ROC analysis was performed to discriminate categories of alcohol intake (heavy versus non-drinkers and heavy versus light drinkers) and AUDIT score in ARIES parents at midlife (left figure) and children at 17 years of age (right figure). ‘Heavy drinkers’ were participants who consumed ≥ 42 g/day in men and ≥ 28 g/day in women (N = 14 at midlife, N = 13 at adolescence); ‘non-drinkers’ consumed 0 g/day (N = 54 at midlife, N = 37 at adolescence); ‘light drinkers’ consume < 0 g per day ≤ 28 in men and < 0 g per day ≤ 14 in women (N = 748 at midlife, N = 417 at adolescence); AUDIT was dichotomised into participants with a score > 15 (N = 23 at midlife, N = 33 at adolescence) and those with a score ≤ 15 (N = 990 at midlife, N = 587 at adolescence). Abbreviations: DNAm-Alcs, DNA methylation alcohol biomarkers; AUDIT, Alcohol Use Disorders Identification Test; ARIES, Accessible Resource for Integrated Epigenomics Studies

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