Skip to main content
Fig. 5 | Clinical Epigenetics

Fig. 5

From: Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma

Fig. 5

Correlations of TIM-3 and LGALS9 methylation and mRNA expression with leukocytes infiltration. Shown are Spearman’s rank correlations (Spearman’s ρ) between methylation/mRNA expression of TIM-3/LGALS9 and leukocyte fraction, as well as tumor infiltrating leukocytes, including lymphocytes (CD8+ T cells, regulatory T cells, T follicular helper cells, T helper cells 1, T helper cells 2, T helper cells 17, γδ T cells, naïve CD4+ T cells, resting and activated memory CD4+ T cells, naïve B cells, memory B cells, plasma cells, resting and activated natural killer cells), monocytes and macrophages (M0/M1/M2 macrophages), resting and activated dendritic cells, resting and activated mast cells, eosinophils, and neutrophils. Immune signatures of tumor infiltrating leukocytes were based on RNAseq analysis and the leukocyte fraction was based on methylation analysis. Only statistically significant (P < 0.05) are shown in color. P values and Spearman’s ρ correlation coefficients can be found in Additional file 1

Back to article page