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Table 4 Cox proportional hazards analysis of disease-free survival and overall survival for GR methylation groups based on C and U region methylation status

From: Region-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancer

Characteristic OS DFS
Hazard ratio [95% CI] P Hazard ratio [95% CI] P
Univariate analysis
 GR methylation group   0.006   0.035
  Both C and U unmethylated 1   1  
  C methylated 0.524 [0.218–1.260] 0.149 0.549 [0.286–1.054] 0.072
  U methylated, no C methylation 2.008 [1.140–3.537] 0.016 1.407 [0.864–2.291] 0.170
Multivariate analysis
 Age   0.083   0.152
  ≤ 45 years 1   1  
  > 45 years 1.624 [0.939–2.810]   1.389 [0.886–2.178]  
 Stage (pathological)   0.985   0.976
  I 1   1  
  II 1.054 [0.167–6.672] 0.955 0.901 [0.179–4.529] 0.899
  III 0.731 [0.005–107.941] 0.902 0.653 [0.015–27.996] 0.824
 Pathological T-stage   0.542   0.558
  T1 1   1  
  T2 1.448 [0.751–2.790] 0.269 1.313 [0.788–2.189] 0.296
  T3/T4 1.401 [0.015–129.717] 0.884 1.830 [0.073–46.030] 0.713
 Nodal status   0.022   0.029
  Node negative 1   1  
  1–3 nodes 1.052 [0.334–3.308] 0.932 1.638 [0.540–4.972] 0.383
  4–9 nodes 1.153 [0.337–3.945] 0.82 1.569 [0.488–5.048] 0.45
  10+ nodes 5.007 [1.201–20.875] 0.027 6.004 [1.494–24.129] 0.012
 Adjuvant chemotherapy   0.517   0.624
  CEF 1   1  
  CMF 1.018 [0.493–2.103] 0.961 0.944 [0.519–1.718] 0.851
  AC 0.698 [0.319–1.526] 0.367 0.755 [0.399–1.426] 0.386
 Treatment   0.552   0.136
  Placebo 1   1  
  Tamoxifen 0.844 [0.484–1.474]   0.710 [0.452–1.115]  
 GR methylation group   0.006   0.041
  Both C and U unmethylated 1   1  
  C methylated 0.504 [0.203–1.255] 0.141 0.559 [0.280–1.115] 0.099
  U methylated, no C methylation 1.988 [1.112–3.553] 0.02 1.431 [0.866–2.365] 0.162
  1. Multivariate Cox proportional hazards models are adjusted for age, pathological stage, pathological T-stage, nodal status, type of adjuvant chemotherapy, and treatment arm, as shown. P values < 0.05 are shown in italics