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Table 4 Cox proportional hazards analysis of disease-free survival and overall survival for GR methylation groups based on C and U region methylation status

From: Region-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancer

Characteristic

OS

DFS

Hazard ratio [95% CI]

P

Hazard ratio [95% CI]

P

Univariate analysis

 GR methylation group

 

0.006

 

0.035

  Both C and U unmethylated

1

 

1

 

  C methylated

0.524 [0.218–1.260]

0.149

0.549 [0.286–1.054]

0.072

  U methylated, no C methylation

2.008 [1.140–3.537]

0.016

1.407 [0.864–2.291]

0.170

Multivariate analysis

 Age

 

0.083

 

0.152

  ≤ 45 years

1

 

1

 

  > 45 years

1.624 [0.939–2.810]

 

1.389 [0.886–2.178]

 

 Stage (pathological)

 

0.985

 

0.976

  I

1

 

1

 

  II

1.054 [0.167–6.672]

0.955

0.901 [0.179–4.529]

0.899

  III

0.731 [0.005–107.941]

0.902

0.653 [0.015–27.996]

0.824

 Pathological T-stage

 

0.542

 

0.558

  T1

1

 

1

 

  T2

1.448 [0.751–2.790]

0.269

1.313 [0.788–2.189]

0.296

  T3/T4

1.401 [0.015–129.717]

0.884

1.830 [0.073–46.030]

0.713

 Nodal status

 

0.022

 

0.029

  Node negative

1

 

1

 

  1–3 nodes

1.052 [0.334–3.308]

0.932

1.638 [0.540–4.972]

0.383

  4–9 nodes

1.153 [0.337–3.945]

0.82

1.569 [0.488–5.048]

0.45

  10+ nodes

5.007 [1.201–20.875]

0.027

6.004 [1.494–24.129]

0.012

 Adjuvant chemotherapy

 

0.517

 

0.624

  CEF

1

 

1

 

  CMF

1.018 [0.493–2.103]

0.961

0.944 [0.519–1.718]

0.851

  AC

0.698 [0.319–1.526]

0.367

0.755 [0.399–1.426]

0.386

 Treatment

 

0.552

 

0.136

  Placebo

1

 

1

 

  Tamoxifen

0.844 [0.484–1.474]

 

0.710 [0.452–1.115]

 

 GR methylation group

 

0.006

 

0.041

  Both C and U unmethylated

1

 

1

 

  C methylated

0.504 [0.203–1.255]

0.141

0.559 [0.280–1.115]

0.099

  U methylated, no C methylation

1.988 [1.112–3.553]

0.02

1.431 [0.866–2.365]

0.162

  1. Multivariate Cox proportional hazards models are adjusted for age, pathological stage, pathological T-stage, nodal status, type of adjuvant chemotherapy, and treatment arm, as shown. P values < 0.05 are shown in italics