Fig. 1
From: A genome-wide DNA methylation signature for SETD1B-related syndrome
The volcano plot of the methylation difference between patients with certain pathogenic variation in SETD1B and healthy individuals (group analysis). The y-axis represents a negative log10 of adj. P-values_M; the x-axis represents the different beta values between patients and controls. Each dot on the plot represents a single CpG site. The horizontal, dotted line represents the statistical significance threshold (adj. P-values_M = 0.05). The vertical, dotted lines show the effect-size threshold (− 0.1 and 0.1). CpGs with adj. P-value_M lesser than 0.05 and an absolute beta difference higher than 0.1 are highlighted in green