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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Hypermethylation of mismatch repair gene hMSH2 associates with platinum-resistant disease in epithelial ovarian cancer

Fig. 3

The methylation level of hMSH2 promoter was associated with platinum-resistant in EOC patients. a Reduced representation bisulfite sequencing (RRBS) assay showed the region (− 1193 to − 1125 upstream) within the promoter of hMSH2 was hypermethylated in platinum-resistant patients compared with platinum-sensitive patients (P = 1.06 × 10−14). b The methylation of − 1164 CpG site was significantly hypermethylated in platinum-resistant patients compared with platinum-sensitive patients by MALDI-TOF mass. c The mRNA expression of hMSH2 in platinum-resistant patients and platinum-sensitive patients. All experiments were repeated three times. d Images shown the expression of hMSH2 protein in EOC tumor tissues. *P < 0.05; **P < 0.01

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