Skip to main content


Fig. 2 | Clinical Epigenetics

Fig. 2

From: Hypermethylation of mismatch repair gene hMSH2 associates with platinum-resistant disease in epithelial ovarian cancer

Fig. 2

The alteration of the sensitivity to cisplatin after a knockdown of hMSH2 expression in A2780 cells. a, b RT-qPCR and western blot assay showed the reduced expression of hMSH2 in sh-hMSH2 cells compared to shNC cells. c CCK-8 assays showed a significant increase in the proliferation rates in the shRNA-hMSH2 cells compared with the shNC cells after cisplatin treatment at several concentrations for 24 h. d Flow cytometry showed that the apoptosis rate in the shRNA-hMSH2 cells was significantly lower than that in the shNC cells after exposure to cisplatin at the 20 μM concentration for 24 h. The A2780 cell apoptosis rates in each group. *P < 0.05; **P < 0.01. The experiments were repeated three times

Back to article page