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Table 6 The summary of the prognostic value of patients with hypermethylated genes compared with those without hypermethylated genes in tissue and plasma samples

From: Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array

 

ADAM19 methylation

FLI1 methylation

MSC methylation

Tissue

Plasma

Tissue

Plasma

Tissue

Plasma

Clinicopathological features

More stage IV GC

More stage IV GC

Fewer early GC

Fewer early GC

None

Fewer superficial GC

Initial recurrence pattern

No correlation

No correlation

More tumor recurrence in the liver, distant lymphatic and para-aortic LN

More liver metastasis

More liver metastasis

No correlation

Patient prognosis

No correlation

No correlation

Independent prognostic factor of OS and DFS

Independent prognostic factor of OS and DFS

No correlation

No correlation

  1. DFS disease-free survival, GC gastric cancer, LN lymph node, OS overall survival