Table 4 The initial recurrence patterns of gastric cancer patients receiving curative surgery with ≥ 2 or < 2 hypermethylated genes in tissue samples according to MSI/EBV status
|  | MSI+ or EBV+ (n = 37) | MSI− and EBV− (n = 82) | ||||
|---|---|---|---|---|---|---|
No. of hypermethylated genes | No. of hypermethylated genes | |||||
< 2 n = 31 | ≥ 2 n = 6 | P value | < 2 n = 69 | ≥ 2 n = 13 | P value | |
Total recurrence | 13 (41.9) | 4 (66.7) | 0.266 | 33 (47.8) | 5 (38.5) | 0.535 |
Locoregional recurrence | 2 (6.5) | 1 (16.7) | 0.401 | 16 (23.2) | 3 (23.1) | 0.993 |
Hepatoduodenal ligament | 1 (3.2) | 0 | 0.656 | 9 (13.0) | 0 | 0.168 |
Abdominal wall | 1 (3.2) | 1 (16.7) | 0.183 | 8 (11.6) | 3 (23.1) | 0.265 |
Perigastric area | 0 | 0 | – | 1 (1.4) | 0 | 0.662 |
Anastomosis | 4 (12.9) | 1 (16.7) | 0.805 | 5 (7.2) | 1 (7.7) | 0.955 |
Distant metastasis | 9 (29.0) | 4 (66.7) | 0.077 | 27 (39.1) | 2 (15.4) | 0.100 |
Peritoneal dissemination | 2 (6.5) | 2 (33.3) | 0.052 | 12 (17.4) | 0 | 0.104 |
Hematogenous metastasis | 6 (19.4) | 3 (50.0) | 0.109 | 10 (14.5) | 1 (7.7) | 0.509 |
Liver | 4 (12.9) | 3 (50.0) | 0.034 | 5 (7.2) | 0 | 0.317 |
Lung | 2 (6.5) | 0 | 0.522 | 3 (4.3) | 0 | 0.444 |
Bone | 1 (3.2) | 0 | 0.656 | 4 (5.8) | 1 (7.7) | 0.793 |
Distant lymphatic recurrence | 2 (6.5) | 1 (16.7) | 0.401 | 9 (13.0) | 1 (7.7) | 0.589 |
Virchow’s node | 0 | 0 | – | 1 (1.4) | 0 | 0.662 |
Lymphangitis carcinomatosa | 0 | 0 | – | 1 (1.4) | 1 (7.7) | 0.181 |
Para-aortic lymph node | 2 (6.5) | 1 (16.7) | 0.401 | 8 (11.6) | 0 | 0.196 |