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Table 4 The initial recurrence patterns of gastric cancer patients receiving curative surgery with ≥ 2 or < 2 hypermethylated genes in tissue samples according to MSI/EBV status

From: Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array

  MSI+ or EBV+ (n = 37) MSI− and EBV− (n = 82)
No. of hypermethylated genes No. of hypermethylated genes
< 2 n = 31 ≥ 2 n = 6 P value < 2 n = 69 ≥ 2 n = 13 P value
Total recurrence 13 (41.9) 4 (66.7) 0.266 33 (47.8) 5 (38.5) 0.535
Locoregional recurrence 2 (6.5) 1 (16.7) 0.401 16 (23.2) 3 (23.1) 0.993
Hepatoduodenal ligament 1 (3.2) 0 0.656 9 (13.0) 0 0.168
Abdominal wall 1 (3.2) 1 (16.7) 0.183 8 (11.6) 3 (23.1) 0.265
Perigastric area 0 0 1 (1.4) 0 0.662
Anastomosis 4 (12.9) 1 (16.7) 0.805 5 (7.2) 1 (7.7) 0.955
Distant metastasis 9 (29.0) 4 (66.7) 0.077 27 (39.1) 2 (15.4) 0.100
Peritoneal dissemination 2 (6.5) 2 (33.3) 0.052 12 (17.4) 0 0.104
Hematogenous metastasis 6 (19.4) 3 (50.0) 0.109 10 (14.5) 1 (7.7) 0.509
Liver 4 (12.9) 3 (50.0) 0.034 5 (7.2) 0 0.317
Lung 2 (6.5) 0 0.522 3 (4.3) 0 0.444
Bone 1 (3.2) 0 0.656 4 (5.8) 1 (7.7) 0.793
Distant lymphatic recurrence 2 (6.5) 1 (16.7) 0.401 9 (13.0) 1 (7.7) 0.589
Virchow’s node 0 0 1 (1.4) 0 0.662
Lymphangitis carcinomatosa 0 0 1 (1.4) 1 (7.7) 0.181
Para-aortic lymph node 2 (6.5) 1 (16.7) 0.401 8 (11.6) 0 0.196
  1. MSI microsatellite instability, EBV Epstein-Barr virus