| |
MSI+ or EBV+ (n = 37)
|
MSI− and EBV− (n = 82)
|
|---|
|
FLI1 hypermethylation
|
MSC hypermethylation
|
FLI1 hypermethylation
|
MSC hypermethylation
|
|---|
|
Without n = 16
|
With n = 21
|
P value
|
Without n = 16
|
With n = 21
|
P value
|
Without n = 54
|
With n = 28
|
P value
|
Without n = 36
|
With n = 46
|
P value
|
|---|
|
Total recurrence
|
6 (37.5)
|
11 (52.4)
|
0.368
|
6 (37.5)
|
11 (52.4)
|
0.368
|
22 (40.7)
|
16 (57.1)
|
0.158
|
16 (44.4)
|
22 (47.8)
|
0.761
|
|
Locoregional recurrence
|
0
|
3 (14.3)
|
0.115
|
1 (6.3)
|
2 (9.5)
|
0.718
|
11 (20.4)
|
8 (28.6)
|
0.404
|
6 (16.7)
|
13 (28.3)
|
0.217
|
|
Hepatoduodenal ligament
|
0
|
1 (4.8)
|
0.376
|
1 (6.3)
|
0
|
0.245
|
5 (9.3)
|
4 (14.3)
|
0.490
|
3 (8.3)
|
6 (13.0)
|
0.498
|
|
Abdominal wall
|
0
|
2 (9.5)
|
0.204
|
0
|
2 (9.5)
|
0.204
|
6 (11.1)
|
5 (17.9)
|
0.395
|
3 (8.3)
|
8 (17.4)
|
0.232
|
|
Perigastric area
|
0
|
0
|
–
|
0
|
0
|
–
|
1 (1.9)
|
0
|
0.469
|
1 (2.8)
|
0
|
0.255
|
|
Anastomosis
|
1 (6.3)
|
4 (19.0)
|
0.259
|
2 (12.5)
|
3 (14.3)
|
0.875
|
3 (5.6)
|
3 (10.7)
|
0.395
|
2 (5.6)
|
4 (8.7)
|
0.588
|
|
Distant metastasis
|
5 (31.3)
|
8 (38.1)
|
0.666
|
3 (18.8)
|
10 (47.6)
|
0.068
|
17 (31.5)
|
12 (42.9)
|
0.307
|
12 (33.3)
|
17 (37.0)
|
0.733
|
|
Peritoneal dissemination
|
1 (6.3)
|
3 (14.3)
|
0.435
|
1 (6.3)
|
3 (14.3)
|
0.435
|
9 (16.7)
|
3 (10.7)
|
0.470
|
6 (16.7)
|
6 (13.0)
|
0.645
|
|
Hematogenous metastasis
|
4 (25.0)
|
5 (23.8)
|
0.933
|
2 (12.5)
|
7 (33.3)
|
0.143
|
5 (9.3)
|
6 (21.4)
|
0.125
|
3 (8.3)
|
8 (17.4)
|
0.232
|
|
Liver
|
2 (12.5)
|
5 (23.8)
|
0.384
|
0
|
7 (33.3)
|
0.010
|
1 (1.9)
|
4 (14.3)
|
0.026
|
1 (2.8)
|
4 (8.7)
|
0.266
|
|
Lung
|
2 (12.5)
|
0
|
0.096
|
2 (12.5)
|
0
|
0.096
|
3 (5.6)
|
0
|
0.204
|
1 (2.8)
|
2 (4.3)
|
0.707
|
|
Bone
|
1 (6.3)
|
0
|
0.245
|
0
|
1 (4.8)
|
0.376
|
3 (5.6)
|
2 (7.1)
|
0.776
|
1 (2.8)
|
4 (8.7)
|
0.266
|
|
Distant lymphatic recurrence
|
0
|
3 (14.3)
|
0.115
|
0
|
3 (14.3)
|
0.115
|
4 (7.4)
|
6 (21.4)
|
0.066
|
3 (8.3)
|
7 (15.2)
|
0.344
|
|
Virchow’s node
|
0
|
0
|
–
|
0
|
0
|
–
|
0
|
1 (3.6)
|
0.162
|
0
|
1 (2.2)
|
0.373
|
|
Lymphangitis carcinomatosa
|
0
|
0
|
–
|
0
|
0
|
–
|
2 (3.7)
|
0
|
0.303
|
0
|
2 (4.3)
|
0.205
|
|
Para-aortic lymph node
|
0
|
3 (14.3)
|
0.115
|
0
|
3 (14.3)
|
0.115
|
3 (3.7)
|
6 (21.4)
|
0.010
|
3 (8.3)
|
5 (10.9)
|
0.701
|
- MSI microsatellite instability, EBV Epstein-Barr virus
