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Table 3 The initial recurrence patterns of gastric cancer patients receiving curative surgery with or without hypermethylation of FLI1 or MSC in tissue samples according to MSI/EBV status
| MSI+ or EBV+ (n = 37) | MSI− and EBV− (n = 82) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FLI1 hypermethylation | MSC hypermethylation | FLI1 hypermethylation | MSC hypermethylation | |||||||||
| Without n = 16 | With n = 21 | P value | Without n = 16 | With n = 21 | P value | Without n = 54 | With n = 28 | P value | Without n = 36 | With n = 46 | P value | |
| Total recurrence | 6 (37.5) | 11 (52.4) | 0.368 | 6 (37.5) | 11 (52.4) | 0.368 | 22 (40.7) | 16 (57.1) | 0.158 | 16 (44.4) | 22 (47.8) | 0.761 |
| Locoregional recurrence | 0 | 3 (14.3) | 0.115 | 1 (6.3) | 2 (9.5) | 0.718 | 11 (20.4) | 8 (28.6) | 0.404 | 6 (16.7) | 13 (28.3) | 0.217 |
| Hepatoduodenal ligament | 0 | 1 (4.8) | 0.376 | 1 (6.3) | 0 | 0.245 | 5 (9.3) | 4 (14.3) | 0.490 | 3 (8.3) | 6 (13.0) | 0.498 |
| Abdominal wall | 0 | 2 (9.5) | 0.204 | 0 | 2 (9.5) | 0.204 | 6 (11.1) | 5 (17.9) | 0.395 | 3 (8.3) | 8 (17.4) | 0.232 |
| Perigastric area | 0 | 0 | – | 0 | 0 | – | 1 (1.9) | 0 | 0.469 | 1 (2.8) | 0 | 0.255 |
| Anastomosis | 1 (6.3) | 4 (19.0) | 0.259 | 2 (12.5) | 3 (14.3) | 0.875 | 3 (5.6) | 3 (10.7) | 0.395 | 2 (5.6) | 4 (8.7) | 0.588 |
| Distant metastasis | 5 (31.3) | 8 (38.1) | 0.666 | 3 (18.8) | 10 (47.6) | 0.068 | 17 (31.5) | 12 (42.9) | 0.307 | 12 (33.3) | 17 (37.0) | 0.733 |
| Peritoneal dissemination | 1 (6.3) | 3 (14.3) | 0.435 | 1 (6.3) | 3 (14.3) | 0.435 | 9 (16.7) | 3 (10.7) | 0.470 | 6 (16.7) | 6 (13.0) | 0.645 |
| Hematogenous metastasis | 4 (25.0) | 5 (23.8) | 0.933 | 2 (12.5) | 7 (33.3) | 0.143 | 5 (9.3) | 6 (21.4) | 0.125 | 3 (8.3) | 8 (17.4) | 0.232 |
| Liver | 2 (12.5) | 5 (23.8) | 0.384 | 0 | 7 (33.3) | 0.010 | 1 (1.9) | 4 (14.3) | 0.026 | 1 (2.8) | 4 (8.7) | 0.266 |
| Lung | 2 (12.5) | 0 | 0.096 | 2 (12.5) | 0 | 0.096 | 3 (5.6) | 0 | 0.204 | 1 (2.8) | 2 (4.3) | 0.707 |
| Bone | 1 (6.3) | 0 | 0.245 | 0 | 1 (4.8) | 0.376 | 3 (5.6) | 2 (7.1) | 0.776 | 1 (2.8) | 4 (8.7) | 0.266 |
| Distant lymphatic recurrence | 0 | 3 (14.3) | 0.115 | 0 | 3 (14.3) | 0.115 | 4 (7.4) | 6 (21.4) | 0.066 | 3 (8.3) | 7 (15.2) | 0.344 |
| Virchow’s node | 0 | 0 | – | 0 | 0 | – | 0 | 1 (3.6) | 0.162 | 0 | 1 (2.2) | 0.373 |
| Lymphangitis carcinomatosa | 0 | 0 | – | 0 | 0 | – | 2 (3.7) | 0 | 0.303 | 0 | 2 (4.3) | 0.205 |
| Para-aortic lymph node | 0 | 3 (14.3) | 0.115 | 0 | 3 (14.3) | 0.115 | 3 (3.7) | 6 (21.4) | 0.010 | 3 (8.3) | 5 (10.9) | 0.701 |
