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Table 3 The initial recurrence patterns of gastric cancer patients receiving curative surgery with or without hypermethylation of FLI1 or MSC in tissue samples according to MSI/EBV status

From: Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array

  MSI+ or EBV+ (n = 37) MSI− and EBV− (n = 82)
FLI1 hypermethylation MSC hypermethylation FLI1 hypermethylation MSC hypermethylation
Without n = 16 With n = 21 P value Without n = 16 With n = 21 P value Without n = 54 With n = 28 P value Without n = 36 With n = 46 P value
Total recurrence 6 (37.5) 11 (52.4) 0.368 6 (37.5) 11 (52.4) 0.368 22 (40.7) 16 (57.1) 0.158 16 (44.4) 22 (47.8) 0.761
Locoregional recurrence 0 3 (14.3) 0.115 1 (6.3) 2 (9.5) 0.718 11 (20.4) 8 (28.6) 0.404 6 (16.7) 13 (28.3) 0.217
Hepatoduodenal ligament 0 1 (4.8) 0.376 1 (6.3) 0 0.245 5 (9.3) 4 (14.3) 0.490 3 (8.3) 6 (13.0) 0.498
Abdominal wall 0 2 (9.5) 0.204 0 2 (9.5) 0.204 6 (11.1) 5 (17.9) 0.395 3 (8.3) 8 (17.4) 0.232
Perigastric area 0 0 – 0 0 – 1 (1.9) 0 0.469 1 (2.8) 0 0.255
Anastomosis 1 (6.3) 4 (19.0) 0.259 2 (12.5) 3 (14.3) 0.875 3 (5.6) 3 (10.7) 0.395 2 (5.6) 4 (8.7) 0.588
Distant metastasis 5 (31.3) 8 (38.1) 0.666 3 (18.8) 10 (47.6) 0.068 17 (31.5) 12 (42.9) 0.307 12 (33.3) 17 (37.0) 0.733
Peritoneal dissemination 1 (6.3) 3 (14.3) 0.435 1 (6.3) 3 (14.3) 0.435 9 (16.7) 3 (10.7) 0.470 6 (16.7) 6 (13.0) 0.645
Hematogenous metastasis 4 (25.0) 5 (23.8) 0.933 2 (12.5) 7 (33.3) 0.143 5 (9.3) 6 (21.4) 0.125 3 (8.3) 8 (17.4) 0.232
Liver 2 (12.5) 5 (23.8) 0.384 0 7 (33.3) 0.010 1 (1.9) 4 (14.3) 0.026 1 (2.8) 4 (8.7) 0.266
Lung 2 (12.5) 0 0.096 2 (12.5) 0 0.096 3 (5.6) 0 0.204 1 (2.8) 2 (4.3) 0.707
Bone 1 (6.3) 0 0.245 0 1 (4.8) 0.376 3 (5.6) 2 (7.1) 0.776 1 (2.8) 4 (8.7) 0.266
Distant lymphatic recurrence 0 3 (14.3) 0.115 0 3 (14.3) 0.115 4 (7.4) 6 (21.4) 0.066 3 (8.3) 7 (15.2) 0.344
Virchow’s node 0 0 – 0 0 – 0 1 (3.6) 0.162 0 1 (2.2) 0.373
Lymphangitis carcinomatosa 0 0 – 0 0 – 2 (3.7) 0 0.303 0 2 (4.3) 0.205
Para-aortic lymph node 0 3 (14.3) 0.115 0 3 (14.3) 0.115 3 (3.7) 6 (21.4) 0.010 3 (8.3) 5 (10.9) 0.701
  1. MSI microsatellite instability, EBV Epstein-Barr virus
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Clinical Epigenetics

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