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Table 2 The patterns of initial recurrence of gastric cancer after curative surgery according to the methylation status of the three genes in the tissue and plasma samples of gastric cancer patient

From: Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array

 

Tissue samples

Plasma samples

Case no.

n = 119

ADAM19

n = 49

P value

FLI1

n = 49

P value

MSC

n = 67

P value

Case no.

n = 93

ADAM19

n = 36

P value

FLI1

n = 42

P value

MSC

n = 47

P value

Total recurrence

55

21 (38.2)

0.579

27 (49.1)

0.135

33 (60.0)

0.465

44

18 (40.9)

0.831

23 (52.3)

0.216

23 (52.3)

0.836

Locoregional recurrence

22

11 (50.0)

0.472

11 (50.0)

0.472

15 (68.2)

0.242

17

9 (52.9)

0.270

10 (58.8)

0.283

11 (64.7)

0.284

Hepatoduodenal ligament

10

5 (50.0)

0.739

5 (50.0)

0.739

6 (60.0)

1.000

6

3 (50.0)

0.674

4 (66.7)

0.404

3 (50.0)

1.000

Abdominal wall

13

7 (53.8)

0.378

7 (53.8)

0.378

10 (76.9)

0.144

11

6 (54.5)

0.327

7 (63.6)

0.214

9 (81.8)

0.050

Perigastric area

1

1 (100)

0.412

0

1.000

0

0.437

1

1 (100)

0.387

0

1.000

0

0.495

Anastomosis

11

4 (36.4)

1.000

7 (63.6)

0.196

7 (63.6)

0.754

10

4 (40.0)

1.000

6 (60.0)

0.339

4 (40.0)

0.523

Distant metastasis

42

16 (38.1)

0.698

20 (47.6)

0.333

27 (64.3)

0.247

32

13 (40.6)

0.825

16 (50.0)

0.519

17 (53.1)

0.828

Peritoneal dissemination

16

6 (37.5)

0.792

6 (37.5)

0.792

9 (56.3)

1.000

13

5 (38.5)

1.000

5 (38.5)

0.766

7 (53.8)

1.000

Hematogenous metastasis

20

7 (35.0)

0.624

11 (55.0)

0.215

15 (75.0)

0.084

14

6 (42.9)

0.771

8 (57.1)

0.390

7 (50.0)

1.000

Liver

12

5 (41.7)

1.000

9 (75.0)

0.026

11 (91.7)

0.012

9

4 (44.4)

0.731

7 (77.8)

0.042

6 (66.4)

0.486

Lung

5

1 (20.0)

0.648

0

0.077

2 (40.0)

0.652

4

1 (25.0)

1.000

0

0.124

0

0.056

Bone

6

1 (16.7)

0.399

2 (33.3)

1.000

5 (83.3)

0.230

4

1 (25.0)

1.000

1 (25.0)

0.624

2 (50.0)

1.000

Distant lymphatic recurrence

13

7 (53.8)

0.378

9 (69.2)

0.038

10 (76.9)

0.144

10

5 (50.0)

0.502

7 (70.0)

0.176

7 (70.0)

0.316

Virchow’s node

1

1 (100)

0.412

1 (100)

0.412

1 (100)

1.000

1

1 (100)

0.387

1 (100)

0.452

1 (100)

1.000

Lymphangitis carcinomatosa

2

1 (50.0)

1.000

0

0.511

2 (100)

0.504

2

1 (50.0)

1.000

0

0.499

1 (50.0)

1.000

Para-aortic lymph node

11

6 (54.5)

0.357

9 (81.8)

0.007

8 (72.7)

0.344

8

4 (50.0)

0.706

7 (87.5)

0.021

6 (75.0)

0.267

  1. Some patients had more than one initial recurrence patterns
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