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Table 2 The patterns of initial recurrence of gastric cancer after curative surgery according to the methylation status of the three genes in the tissue and plasma samples of gastric cancer patient

From: Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array

  Tissue samples Plasma samples
Case no. n = 119 ADAM19 n = 49 P value FLI1 n = 49 P value MSC n = 67 P value Case no. n = 93 ADAM19 n = 36 P value FLI1 n = 42 P value MSC n = 47 P value
Total recurrence 55 21 (38.2) 0.579 27 (49.1) 0.135 33 (60.0) 0.465 44 18 (40.9) 0.831 23 (52.3) 0.216 23 (52.3) 0.836
Locoregional recurrence 22 11 (50.0) 0.472 11 (50.0) 0.472 15 (68.2) 0.242 17 9 (52.9) 0.270 10 (58.8) 0.283 11 (64.7) 0.284
Hepatoduodenal ligament 10 5 (50.0) 0.739 5 (50.0) 0.739 6 (60.0) 1.000 6 3 (50.0) 0.674 4 (66.7) 0.404 3 (50.0) 1.000
Abdominal wall 13 7 (53.8) 0.378 7 (53.8) 0.378 10 (76.9) 0.144 11 6 (54.5) 0.327 7 (63.6) 0.214 9 (81.8) 0.050
Perigastric area 1 1 (100) 0.412 0 1.000 0 0.437 1 1 (100) 0.387 0 1.000 0 0.495
Anastomosis 11 4 (36.4) 1.000 7 (63.6) 0.196 7 (63.6) 0.754 10 4 (40.0) 1.000 6 (60.0) 0.339 4 (40.0) 0.523
Distant metastasis 42 16 (38.1) 0.698 20 (47.6) 0.333 27 (64.3) 0.247 32 13 (40.6) 0.825 16 (50.0) 0.519 17 (53.1) 0.828
Peritoneal dissemination 16 6 (37.5) 0.792 6 (37.5) 0.792 9 (56.3) 1.000 13 5 (38.5) 1.000 5 (38.5) 0.766 7 (53.8) 1.000
Hematogenous metastasis 20 7 (35.0) 0.624 11 (55.0) 0.215 15 (75.0) 0.084 14 6 (42.9) 0.771 8 (57.1) 0.390 7 (50.0) 1.000
Liver 12 5 (41.7) 1.000 9 (75.0) 0.026 11 (91.7) 0.012 9 4 (44.4) 0.731 7 (77.8) 0.042 6 (66.4) 0.486
Lung 5 1 (20.0) 0.648 0 0.077 2 (40.0) 0.652 4 1 (25.0) 1.000 0 0.124 0 0.056
Bone 6 1 (16.7) 0.399 2 (33.3) 1.000 5 (83.3) 0.230 4 1 (25.0) 1.000 1 (25.0) 0.624 2 (50.0) 1.000
Distant lymphatic recurrence 13 7 (53.8) 0.378 9 (69.2) 0.038 10 (76.9) 0.144 10 5 (50.0) 0.502 7 (70.0) 0.176 7 (70.0) 0.316
Virchow’s node 1 1 (100) 0.412 1 (100) 0.412 1 (100) 1.000 1 1 (100) 0.387 1 (100) 0.452 1 (100) 1.000
Lymphangitis carcinomatosa 2 1 (50.0) 1.000 0 0.511 2 (100) 0.504 2 1 (50.0) 1.000 0 0.499 1 (50.0) 1.000
Para-aortic lymph node 11 6 (54.5) 0.357 9 (81.8) 0.007 8 (72.7) 0.344 8 4 (50.0) 0.706 7 (87.5) 0.021 6 (75.0) 0.267
  1. Some patients had more than one initial recurrence patterns