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Table 5 PEAR1 Factor2 methylation association with markers of cell and plasmatic inflammation partially depends upon platelet activation n the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

 

Model A

Model B

Beta

SE

p value

R-square

Beta

SE

p value

R-square

Soluble P-selectin

− 0.197

0.057

< 0.0001

0.100

− 0.207

0.054

0.0002

0.051

Monocyte CD11b

0.034

0.057

0.549

0.005

0.021

0.057

0.719

0.0004

PMN CD11b

0.122

0.058

0.035

0.043

0.144

0.058

0.014

0.020

Monocyte L-selectin

0.155

0.065

0.019

0.021

0.127

0.066

0.056

0.013

PMN L-selectin

0.151

0.061

0.015

0.059

0.183

0.063

0.004

0.030

CRP

− 0.078

0.053

0.145

0.016

− 0.087

0.054

0.112

0.009

INFLAscorea

− 0.143

0.058

0.014

0.026

− 0.111

0.059

0.057

0.012

  1. Model A adjusted by age, gender, BMI, smoking (being an ever smoker and pack-years), drinking (a drinker was defined as drinking daily more than 15 g of alcohol), being a proband for family recruitment, being a member of MI family as fixed effects, and family as a random effect. Model B is Model A +adjustment by platelets, PDW, platelet P-selectin, platelet/monocyte, and platelet/PMN. aINFLAscore was adjusted only for PDW, soluble P-selectin, platelet P-selectin, platelet-monocyte aggregates, and platelet-PMN aggregates, but not platelet number, as this variable is accounted in its formula. R-squares were calculated using a linear regression model including covariates used as fixed effect in the mixed models. Standardized values of phenotypes and methylation are reported. Significant p values are reported in italics
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Clinical Epigenetics

ISSN: 1868-7083

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