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Table 5 PEAR1 Factor2 methylation association with markers of cell and plasmatic inflammation partially depends upon platelet activation n the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

  Model A Model B
Beta SE p value R-square Beta SE p value R-square
Soluble P-selectin − 0.197 0.057 < 0.0001 0.100 − 0.207 0.054 0.0002 0.051
Monocyte CD11b 0.034 0.057 0.549 0.005 0.021 0.057 0.719 0.0004
PMN CD11b 0.122 0.058 0.035 0.043 0.144 0.058 0.014 0.020
Monocyte L-selectin 0.155 0.065 0.019 0.021 0.127 0.066 0.056 0.013
PMN L-selectin 0.151 0.061 0.015 0.059 0.183 0.063 0.004 0.030
CRP − 0.078 0.053 0.145 0.016 − 0.087 0.054 0.112 0.009
INFLAscorea − 0.143 0.058 0.014 0.026 − 0.111 0.059 0.057 0.012
  1. Model A adjusted by age, gender, BMI, smoking (being an ever smoker and pack-years), drinking (a drinker was defined as drinking daily more than 15 g of alcohol), being a proband for family recruitment, being a member of MI family as fixed effects, and family as a random effect. Model B is Model A +adjustment by platelets, PDW, platelet P-selectin, platelet/monocyte, and platelet/PMN. aINFLAscore was adjusted only for PDW, soluble P-selectin, platelet P-selectin, platelet-monocyte aggregates, and platelet-PMN aggregates, but not platelet number, as this variable is accounted in its formula. R-squares were calculated using a linear regression model including covariates used as fixed effect in the mixed models. Standardized values of phenotypes and methylation are reported. Significant p values are reported in italics