Skip to main content

Advertisement

Table 4 Platelets do not influence the association between Factor2 PEAR1 methylation and WBC counts in the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

  Model A Model B
Beta SE p value R-square Beta SE p value R-square
WBC − 0.123 0.058 0.036 0.020 − 0.150 0.054 0.006 0.025
Lymphocytes 0.210 0.055 0.0002 0.009 0.224 0.056 < 0.0001 0.051
Monocytes 0.239 0.055 < 0.0001 0.023 0.268 0.057 < 0.0001 0.069
Granulocytes − 0.275 0.055 < 0.0001 0.046 − 0.286 0.056 < 0.0001 0.079
  1. Model A adjusted by age, gender, BMI, smoking (being an ever smoker and pack-years), drinking (a drinker was defined as drinking daily more than 15 g of alcohol), being a proband for family recruitment, being a member of MI family as fixed effects, and family as a random effect. Model B is Model A +adjustment by platelets, PDW, platelet P-selectin, platelet/monocyte, and platelet/PMN. R-squares were calculated using a linear regression model including covariates used as fixed effect in the mixed models. Standardized values of phenotypes and methylation are reported. Significant p values are reported in italics