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Table 4 Platelets do not influence the association between Factor2 PEAR1 methylation and WBC counts in the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

 

Model A

Model B

Beta

SE

p value

R-square

Beta

SE

p value

R-square

WBC

− 0.123

0.058

0.036

0.020

− 0.150

0.054

0.006

0.025

Lymphocytes

0.210

0.055

0.0002

0.009

0.224

0.056

< 0.0001

0.051

Monocytes

0.239

0.055

< 0.0001

0.023

0.268

0.057

< 0.0001

0.069

Granulocytes

− 0.275

0.055

< 0.0001

0.046

− 0.286

0.056

< 0.0001

0.079

  1. Model A adjusted by age, gender, BMI, smoking (being an ever smoker and pack-years), drinking (a drinker was defined as drinking daily more than 15 g of alcohol), being a proband for family recruitment, being a member of MI family as fixed effects, and family as a random effect. Model B is Model A +adjustment by platelets, PDW, platelet P-selectin, platelet/monocyte, and platelet/PMN. R-squares were calculated using a linear regression model including covariates used as fixed effect in the mixed models. Standardized values of phenotypes and methylation are reported. Significant p values are reported in italics
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Clinical Epigenetics

ISSN: 1868-7083

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