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Table 3 PEAR1 methylation is significantly associated with PDW, WBC, lymphocyte, monocyte, and neutrophil counts in the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

  Factor1 Factor2 P1 P2 P28_29
Beta SE p value R-square Beta SE p value R-square Beta SE p value R-square Beta SE p value R-square Beta SE p value R-square
Platelets − 0.088 0.048 0.071 0.006 0.083 0.052 0.109 0.007 0.009 0.038 0.800 0.000 − 0.011 0.042 0.788 0.000 − 0.025 0.038 0.500 0.001
MPV − 0.033 0.053 0.530 0.001 0.001 0.058 0.993 0.000 0.017 0.040 0.679 0.000 − 0.004 0.044 0.928 0.000 0.048 0.041 0.233 0.004
Pct − 0.105 0.049 0.034 0.008 0.100 0.053 0.058 0.007 0.014 0.038 0.790 0.000 − 0.001 0.042 0.979 0.000 − 0.005 0.038 0.888 0.000
PDW 0.023 0.056 0.677 0.002 0.145 0.058 0.013 0.026 0.052 0.043 0.223 0.002 − 0.052 0.045 0.249 0.000 − 0.010 0.041 0.800 0.000
WBC − 0.047 0.056 0.397 0.001 − 0.123 0.058 0.036 0.020 − 0.018 0.041 0.657 0.000 − 0.066 0.045 0.143 0.008 0.001 0.041 0.989 0.000
Lymphocytes 0.126 0.053 0.019 0.002 0.210 0.055 0.0002 0.009 0.027 0.041 0.521 0.000 0.097 0.044 0.028 0.001 0.006 0.041 0.887 0.000
Monocytes − 0.085 0.052 0.105 0.005 0.239 0.055 < 0.0001 0.023 0.075 0.037 0.045 0.005 0.040 0.041 0.327 0.001 0;015 0.037 0.691 0.000
Neutrophils − 0.105 0.055 0.081 0.003 − 0.275 0.055 < 0.0001 0.046 − 0.049 0.041 0.228 0.001 − 0.104 0.044 0.019 0.009 − 0.008 0.040 0.851 0.000
  1. Model adjusted by age, gender, BMI, smoking (being an ever smoker and pack-years), drinking (a drinker was defined as drinking daily more than 15 g of alcohol), being a proband for family recruitment, being a member of MI family as fixed effects, and family as a random effect. R-squares were calculated using a linear regression model including covariates used as fixed effect in the mixed models. Standardized values of phenotypes and methylation are reported. Significant p values are reported in italics