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Table 3 PEAR1 methylation is significantly associated with PDW, WBC, lymphocyte, monocyte, and neutrophil counts in the Moli-family cohort

From: Variation of PEAR1 DNA methylation influences platelet and leukocyte function

 

Factor1

Factor2

P1

P2

P28_29

Beta

SE

p value

R-square

Beta

SE

p value

R-square

Beta

SE

p value

R-square

Beta

SE

p value

R-square

Beta

SE

p value

R-square

Platelets

− 0.088

0.048

0.071

0.006

0.083

0.052

0.109

0.007

0.009

0.038

0.800

0.000

− 0.011

0.042

0.788

0.000

− 0.025

0.038

0.500

0.001

MPV

− 0.033

0.053

0.530

0.001

0.001

0.058

0.993

0.000

0.017

0.040

0.679

0.000

− 0.004

0.044

0.928

0.000

0.048

0.041

0.233

0.004

Pct

− 0.105

0.049

0.034

0.008

0.100

0.053

0.058

0.007

0.014

0.038

0.790

0.000

− 0.001

0.042

0.979

0.000

− 0.005

0.038

0.888

0.000

PDW

0.023

0.056

0.677

0.002

0.145

0.058

0.013

0.026

0.052

0.043

0.223

0.002

− 0.052

0.045

0.249

0.000

− 0.010

0.041

0.800

0.000

WBC

− 0.047

0.056

0.397

0.001

− 0.123

0.058

0.036

0.020

− 0.018

0.041

0.657

0.000

− 0.066

0.045

0.143

0.008

0.001

0.041

0.989

0.000

Lymphocytes

0.126

0.053

0.019

0.002

0.210

0.055

0.0002

0.009

0.027

0.041

0.521

0.000

0.097

0.044

0.028

0.001

0.006

0.041

0.887

0.000

Monocytes

− 0.085

0.052

0.105

0.005

0.239

0.055

< 0.0001

0.023

0.075

0.037

0.045

0.005

0.040

0.041

0.327

0.001

0;015

0.037

0.691

0.000

Neutrophils

− 0.105

0.055

0.081

0.003

− 0.275

0.055

< 0.0001

0.046

− 0.049

0.041

0.228

0.001

− 0.104

0.044

0.019

0.009

− 0.008

0.040

0.851

0.000

  1. Model adjusted by age, gender, BMI, smoking (being an ever smoker and pack-years), drinking (a drinker was defined as drinking daily more than 15 g of alcohol), being a proband for family recruitment, being a member of MI family as fixed effects, and family as a random effect. R-squares were calculated using a linear regression model including covariates used as fixed effect in the mixed models. Standardized values of phenotypes and methylation are reported. Significant p values are reported in italics