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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Methylation estimates the risk of precancer in HPV-infected women with discrepant results between cytology and HPV16/18 genotyping

Fig. 3

Receiver operator characteristic (ROC) and area under the curve (AUC) of S5 methylation for detecting CIN2+ or CIN3+. The blue diamond denotes the sensitivity and specificity of S5 at a cutoff of 3.7 for CIN2+. The red circle denotes the sensitivity and specificity at the S5 cutoff of 0.8 predefined for use in the UK for CIN2+. The cutoff for cytology alone was ASCUS+. Abbreviations: ASCUS+, atypical squamous cells of undetermined significance or worse

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