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Table 3 Uni- and multivariate cox regression of the MEIS2 methylation model in the 450K TCGA cohort (n = 389)

From: Epigenetic silencing of MEIS2 in prostate cancer recurrence

Variable Univariate Multivariate
HR (CI) p value C-index HR (CI) p value C-index
MEIS2 model meth. Low vs. high 2.48 (1.26–4.88) 0.009 0.618 2.02 (1.02–3.99) 0.042 0.710
Gleason score < 7 1 0.646 1
= 7 2.77 (0.63–12.13) 0.176 1.64 (0.37–7.27) 0.517
> 7 7.53 (1.80–31.58) 0.006 3.63 (0.84–15.69) 0.085
Path. T-stage T2 vs. T3 6.02 (2.16–16.81) 0.001 0.617 3.97 (1.38–11.43) 0.011
Surgical margin status Neg. vs. pos. 1.47 (0.82–2.65) 0.198 0.542
  1. BCR was used as end-point. Meth. methylation, Path. pathologic, HR hazard ratio, CI confidence interval