Table 3 Uni- and multivariate cox regression of the MEIS2 methylation model in the 450K TCGA cohort (n = 389)
From: Epigenetic silencing of MEIS2 in prostate cancer recurrence
Variable | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
HR (CI) | p value | C-index | HR (CI) | p value | C-index | ||
MEIS2 model meth. | Low vs. high | 2.48 (1.26–4.88) | 0.009 | 0.618 | 2.02 (1.02–3.99) | 0.042 | 0.710 |
Gleason score | < 7 | 1 | 0.646 | 1 | |||
= 7 | 2.77 (0.63–12.13) | 0.176 | 1.64 (0.37–7.27) | 0.517 | |||
> 7 | 7.53 (1.80–31.58) | 0.006 | 3.63 (0.84–15.69) | 0.085 | |||
Path. T-stage | T2 vs. T3 | 6.02 (2.16–16.81) | 0.001 | 0.617 | 3.97 (1.38–11.43) | 0.011 | |
Surgical margin status | Neg. vs. pos. | 1.47 (0.82–2.65) | 0.198 | 0.542 | – | – | – |