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Table 2 Uni- and multivariate cox regression of the MEIS2 methylation model in RP patients analyzed by qMSP (n = 192)

From: Epigenetic silencing of MEIS2 in prostate cancer recurrence

Variable Univariate Multivariate
HR (CI) p value C-index HR (CI) p value C-index
MEIS2 model meth. Low vs. high 1.79 (1.17–2.76) 0.008 0.573 1.10 (0.69–1.75) 0.681 0.730
Path. Gleason Score < 7 Ref 0.647 Ref
= 7 2.79 (1.63–4.76) 0.000 2.91 (1.67–5.07) 0.000
> 7 5.28 (2.92–9.56) 0.000 4.22 (2.26–7.87) 0.000
Path. T-stage T2 vs. T3 3.16 (2.13–4.68) 0.000 0.634 2.22 (1.33–3.68) 0.002
Surgical margin status Neg vs. pos. 2.91 (1.96–4.33) 0.000 0.626 1.50 (0.90–2.51) 0.120
Path. N-stage pN0 vs. pN1 0.53 (0.22–1.31) 0.169 0.523
  1. BCR was used as endpoint. Meth. methylation, Path. pathologic, HR hazard ratio, CI confidence interval