Table 2 Uni- and multivariate cox regression of the MEIS2 methylation model in RP patients analyzed by qMSP (n = 192)
From: Epigenetic silencing of MEIS2 in prostate cancer recurrence
Variable | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|
HR (CI) | p value | C-index | HR (CI) | p value | C-index | ||
MEIS2 model meth. | Low vs. high | 1.79 (1.17–2.76) | 0.008 | 0.573 | 1.10 (0.69–1.75) | 0.681 | 0.730 |
Path. Gleason Score | < 7 | Ref | 0.647 | Ref | |||
= 7 | 2.79 (1.63–4.76) | 0.000 | 2.91 (1.67–5.07) | 0.000 | |||
> 7 | 5.28 (2.92–9.56) | 0.000 | 4.22 (2.26–7.87) | 0.000 | |||
Path. T-stage | T2 vs. T3 | 3.16 (2.13–4.68) | 0.000 | 0.634 | 2.22 (1.33–3.68) | 0.002 | |
Surgical margin status | Neg vs. pos. | 2.91 (1.96–4.33) | 0.000 | 0.626 | 1.50 (0.90–2.51) | 0.120 | |
Path. N-stage | pN0 vs. pN1 | 0.53 (0.22–1.31) | 0.169 | 0.523 | – | – | – |