Skip to main content

Advertisement

Table 9 Effects of DNA methylation and the interaction with B vitamin biomarkers on global and domain-specific cognitive performance

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

Cognitive performance NUDT15 NUDT15×Folate NUDT15×Hcy TXNRD1 TXNRD1×Folate TXNRD1×Hcy
MMSE B − 0.018 0.044 − 0.082 − 0.005 0.147 − 0.103
P value 0.809 0.559 0.287 0.947 0.048* 0.178
MoCA B − 0.127 0.096 − 0.325 − 0.124 0.268 − 0.345
P value 0.077 0.183 < 0.001* 0.082 < 0.001* < 0.001*
AVLT-IR B − 0.026 0.102 − 0.125 − 0.123 0.163 − 0.259
P value 0.752 0.208 0.130 0.126 0.042* 0.001*
AVLT-SR B 0.013 0.066 − 0.055 − 0.082 0.022 − 0.151
P value 0.870 0.39 0.489 0.283 0.775 0.056
AVLT-LR B − 0.004 0.063 − 0.062 − 0.054 0.090 − 0.151
P value 0.960 0.421 0.442 0.487 0.251 0.060
SDMT B − 0.086 − 0.002 − 0.132 − 0.090 0.051 − 0.137
P value 0.213 0.980 0.059 0.185 0.456 0.049*
LMT B − 0.046 0.098 − 0.187 − 0.129 0.091 − 0.269
P value 0.549 0.194 0.015* 0.186 0.231 < 0.001*
DSF B − 0.087 0.034 − 0.221 − 0.095 0.106 − 0.252
P value 0.262 0.664 0.005* 0.223 0.174 0.001*
DSB B − 0.064 − 0.003 − 0.079 0.020 0.118 − 0.052
P value 0.410 0.969 0.314 0.797 0.127 0.509
  1. MMSE mini-mental state examination, MoCA Montreal Cognitive Assessment, AVLT-IR auditory verbal learning test-immediate recall, AVLT-SR auditory verbal learning test-short recall, AVLT-LR auditory verbal learning test-long recall, SDMT symbol digit modalities test, LMT logical memory test, DSF digit span forwards, DSB digit span backwards, Hcy homocysteine, NUDT15 nudix hydrolase 15, TXNRD1 thioredoxin reductase 1
  2. B: standardized regression coefficients of multiple linear regression
  3. P < 0.05