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Table 8 Correlations for serum B vitamin biomarkers, oxidative biomarkers, and DNA methylation of NUDT15 and TXNRD1 genes

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

  NUDT15_CpG_17 NUDT15_CpG_19 TXNRD1_CpG_9 TXNRD1_CpG_11
r FDR adjusted P value r FDR adjusted P value r FDR adjusted P value r FDR adjusted P value
B vitamin and metabolites
Folate (μg/L) − 0.101 0.417 − 0.219 0.028* − 0.201 0.133 − 0.192 0.041*
Vitamin B6 (ng/L) − 0.030 0.815 − 0.074 0.559 0.009 0.949 0.029 0.930
Vitamin B12 (ng/L) 0.022 0.962 0.041 0.930 0.086 0.738 0.079 0.738
Hcy (μmol/L) 0.098 0.434 0.251 0.010* 0.198 0.133 0.225 0.045*
Oxidative biomarkers
ROS (IU/ml) 0.069 0.762 0.230 0.020* 0.164 0.169 0.157 0.176
MDA (mmol/L) 0.068 0.561 0.125 0.268 0.143 0.236 0.123 0.296
8-OHdG (ng/L) 0.132 0.248 0.259 0.008* 0.180 0.145 0.171 0.121
8-iso-PGF2α (ng/L) 0.130 0.248 0.183 0.074 0.154 0.210 0.192 0.042*
  1. Hcy homocysteine, ROS reactive oxygen species, MDA malondialdehyde, 8-OHdG 8-hydroxy-desoxyguanosine, 8-iso-PGF2α 8-iso-prostaglandin F2α, FDR false discovery rate, NUDT15 nudix hydrolase 15, TXNRD1 thioredoxin reductase 1
  2. P < 0.05