Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

Table 8 Correlations for serum B vitamin biomarkers, oxidative biomarkers, and DNA methylation of NUDT15 and TXNRD1 genes

	NUDT15_CpG_17		NUDT15_CpG_19		TXNRD1_CpG_9		TXNRD1_CpG_11
	r	FDR adjusted P value	r	FDR adjusted P value	r	FDR adjusted P value	r	FDR adjusted P value
B vitamin and metabolites
Folate (μg/L)	− 0.101	0.417	− 0.219	0.028*	− 0.201	0.133	− 0.192	0.041*
Vitamin B₆ (ng/L)	− 0.030	0.815	− 0.074	0.559	0.009	0.949	0.029	0.930
Vitamin B₁₂ (ng/L)	0.022	0.962	0.041	0.930	0.086	0.738	0.079	0.738
Hcy (μmol/L)	0.098	0.434	0.251	0.010*	0.198	0.133	0.225	0.045*
Oxidative biomarkers
ROS (IU/ml)	0.069	0.762	0.230	0.020*	0.164	0.169	0.157	0.176
MDA (mmol/L)	0.068	0.561	0.125	0.268	0.143	0.236	0.123	0.296
8-OHdG (ng/L)	0.132	0.248	0.259	0.008*	0.180	0.145	0.171	0.121
8-iso-PGF2α (ng/L)	0.130	0.248	0.183	0.074	0.154	0.210	0.192	0.042*

Hcy homocysteine, ROS reactive oxygen species, MDA malondialdehyde, 8-OHdG 8-hydroxy-desoxyguanosine, 8-iso-PGF2α 8-iso-prostaglandin F2α, FDR false discovery rate, NUDT15 nudix hydrolase 15, TXNRD1 thioredoxin reductase 1
^∗P < 0.05

ISSN: 1868-7083