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Table 6 Correlations between serum B vitamin biomarkers and oxidative biomarkers

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

  Oxidative biomarkers
ROS (IU/ml) MDA (mmol/L) 8-OHdG (ng/L) 8-iso-PGF2α (ng/L)
r FDR adjusted P value r FDR adjusted P value r FDR adjusted P value r FDR adjusted P value
Serum B vitamin biomarkers
Folate (μg/L) − 0.507 < 0.001* − 0.432 < 0.001* − 0.653 < 0.001* − 0.568 < 0.001*
Vitamin B6 (ng/L) 0.069 0.742 0.155 0.293 − 0.008 0.991 0.194 0.223
Vitamin B12 (ng/L) 0.114 0.588 0.109 0.588 0.220 0.097 0.177 0.194
Hcy (μmol/L) 0.564 < 0.001* 0.400 < 0.001* 0.666 < 0.001* 0.547 < 0.001*
  1. Hcy homocysteine, ROS reactive oxygen species, MDA malondialdehyde, 8-OHdG 8-hydroxy-desoxyguanosine, 8-iso-PGF2α 8-iso-prostaglandin F2α, FDR false discovery rate
  2. P < 0.05