Skip to main content

Table 2 Longitudinal associations of dietary intake of vitamin B6 with global and domain-specific cognitive decline

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

Cognitive performance

Vitamin B6 (mg/day)

1st quartile

2nd quartile

3rd quartile

4th quartile

MMSE

B (95%CI)

Ref

− 0.04 (− 0.17, 0.10)

− 0.13 (− 0.29, 0.02)

− 0.07 (− 0.27, 0.13)

P value

Ref

0.586

0.091

0.499

MoCA

B (95%CI)

Ref

− 0.06 (− 0.27, 0.14)

− 0.26 (− 0.56, 0.04)

− 0.31 (− 0.55, − 0.08)

P value

Ref

0.555

0.094

0.009*

AVLT-IR

B (95%CI)

Ref

0.35 (0.03, 0.68)

0.40 (0.03, 0.77)

0.66 (0.18, 1.14)

P value

Ref

0.033*

0.034*

0.007*

AVLT-SR

B (95%CI)

Ref

0.33 (0.17, 0.50)

0.30 (0.12, 0.49)

0.46 (0.22, 0.70)

P value

Ref

< 0.001*

0.002*

< 0.001*

AVLT-LR

B (95%CI)

Ref

0.25 (0.07, 0.43)

0.39 (0.12, 0.65)

0.19 (− 0.02, 0.40)

P value

Ref

0.007*

0.004*

0.069

SDMT

B (95%CI)

Ref

1.13 (0.44, 1.82)

0.76 (− 0.03, 1.55)

− 0.22 (− 1.23, 0.79)

P value

Ref

0.001*

0.058

0.669

LMT

B (95%CI)

Ref

0.20 (− 0.24, 0.63)

− 0.06 (− 0.56, 0.43)

− 0.16 (− 0.80, 0.48)

P value

Ref

0.376

0.799

0.625

DSF

B (95%CI)

Ref

− 0.02 (− 0.11, 0.07)

− 0.04 (− 0.15, 0.06)

− 0.17 (− 0.30, − 0.04)

P value

Ref

0.664

0.427

0.012*

DSB

B (95%CI)

Ref

0.03 (− 0.06, 0.11)

− 0.03 (− 0.12, 0.07)

− 0.05 (− 0.17, 0.07)

P value

Ref

0.512

0.604

0.426

  1. MMSE mini-mental state examination, MoCA Montreal Cognitive Assessment, AVLT-IR auditory verbal learning test-immediate recall, AVLT-SR auditory verbal learning test-short recall, AVLT-LR auditory verbal learning test-long recall, SDMT symbol digit modalities test, LMT logical memory test, DSF digit span forwards, DSB digit span backwards
  2. B: regression coefficients of linear mixed-effect models
  3. ∗P < 0.05