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Table 2 Longitudinal associations of dietary intake of vitamin B6 with global and domain-specific cognitive decline

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

Cognitive performance Vitamin B6 (mg/day)
1st quartile 2nd quartile 3rd quartile 4th quartile
MMSE B (95%CI) Ref − 0.04 (− 0.17, 0.10) − 0.13 (− 0.29, 0.02) − 0.07 (− 0.27, 0.13)
P value Ref 0.586 0.091 0.499
MoCA B (95%CI) Ref − 0.06 (− 0.27, 0.14) − 0.26 (− 0.56, 0.04) − 0.31 (− 0.55, − 0.08)
P value Ref 0.555 0.094 0.009*
AVLT-IR B (95%CI) Ref 0.35 (0.03, 0.68) 0.40 (0.03, 0.77) 0.66 (0.18, 1.14)
P value Ref 0.033* 0.034* 0.007*
AVLT-SR B (95%CI) Ref 0.33 (0.17, 0.50) 0.30 (0.12, 0.49) 0.46 (0.22, 0.70)
P value Ref < 0.001* 0.002* < 0.001*
AVLT-LR B (95%CI) Ref 0.25 (0.07, 0.43) 0.39 (0.12, 0.65) 0.19 (− 0.02, 0.40)
P value Ref 0.007* 0.004* 0.069
SDMT B (95%CI) Ref 1.13 (0.44, 1.82) 0.76 (− 0.03, 1.55) − 0.22 (− 1.23, 0.79)
P value Ref 0.001* 0.058 0.669
LMT B (95%CI) Ref 0.20 (− 0.24, 0.63) − 0.06 (− 0.56, 0.43) − 0.16 (− 0.80, 0.48)
P value Ref 0.376 0.799 0.625
DSF B (95%CI) Ref − 0.02 (− 0.11, 0.07) − 0.04 (− 0.15, 0.06) − 0.17 (− 0.30, − 0.04)
P value Ref 0.664 0.427 0.012*
DSB B (95%CI) Ref 0.03 (− 0.06, 0.11) − 0.03 (− 0.12, 0.07) − 0.05 (− 0.17, 0.07)
P value Ref 0.512 0.604 0.426
  1. MMSE mini-mental state examination, MoCA Montreal Cognitive Assessment, AVLT-IR auditory verbal learning test-immediate recall, AVLT-SR auditory verbal learning test-short recall, AVLT-LR auditory verbal learning test-long recall, SDMT symbol digit modalities test, LMT logical memory test, DSF digit span forwards, DSB digit span backwards
  2. B: regression coefficients of linear mixed-effect models
  3. P < 0.05