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Table 4 The 20 most differentially methylated regions (DMRs) associated with the emergence of dimensional psychopathology

From: Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths

hg19 genomic coordinates N probes Mean β FC Combined p value Gene annotation
chr10:133,747,120-133,748,048 9 0.025 6.44 × 10−04 PPP2R2D (TSS1500; 5′UTR; First Exon; body)
chr6:22,297,336-22,298,146 4 0.042 1.49 × 10−03 PRL (TSS1500; 5′UTR; First Exon)
chr7:158,669,801-158,669,978 5 0.019 1.90 × 10−03 WDR60 (body)
chr5:40,908,228-40,908,780 4 0.040 2.25 × 10−03 C7 (TSS1500)
chr5:132,200,008-132,200,666 6 0.016 2.27 × 10−03 GDF9 (TSS200; First Exon)
chr1:169,702,841-169,703,751 4 0.029 3.41 × 10− 03 SELE (TSS1500; 5′UTR)
chr7:95,114,680-95,115,354 8 0.024 4.84 × 10− 03 ASB4 (TSS1500; First Exon)
chr7:54,794,693-54,794,760 3 0.038 4.94 × 10−03
chr6:28,540,442-28,541,039 5 0.021 6.01 × 10−03 SCAND3 (body)
chr6:3,129,395-3,129,410 3 0.025 6.11 × 10−03 BPHL (Body); SNORD6 (TSS200); SNORA32 (TSS1500); SNORA25 (TSS1500)
chr6:125,623,465-125,623,573 3 0.035 6.28 × 10−03 HDDC2 (TSS1500; TSS200)
chr13:36,421,844-36,421,949 3 0.060 6.33 × 10−03 MIR548F5 (body)/DCLK1 (body)
chr20:39,666,232-39,666,765 3 0.042 6.55 × 10−03 TOP1 (body)/PRO0628 (TSS1500; body)
chr10:682,147-682,486 4 0.037 8.01 × 10−03 DIP2C (body)
chr19:46,999,055-46,999,118 3 0.039 8.13 × 10−03 PNMAL2 (5′UTR; First Exon)
chr3:75,263,619-75,263,641 3 0.039 9.35 × 10−03
chr19:55,889,013-55,889,387 4 0.032 0.011 TMEM190 (body)
chr15:28,272,345-28,272,656 3 0.019 0.012 OCA2 (body)
chr11:63,136,414-63,137,125 3 0.040 0.012 SLC22A9 (TSS1500; TSS200)
chr4:76,995,173-76,995,796 4 0.018 0,013 ART3 (TSS1500; TSS200; 5′UTR)
  1. Wave 0 was used as the reference. Gene annotations were taken from Illumina reference files. N probes number of probes included in the differentially methylated region. Mean β FC mean β fold change for the region. Combined p value Stouffer transformation of the FDRs for individual CpG sites that constituted the DMR. TSS200 0–200 bases upstream of the transcriptional start site (TSS). TSS1500 200–1500 bases upstream of the TSS