Table 4 The 20 most differentially methylated regions (DMRs) associated with the emergence of dimensional psychopathology
hg19 genomic coordinates | N probes | Mean β FC | Combined p value | Gene annotation |
|---|---|---|---|---|
chr10:133,747,120-133,748,048 | 9 | 0.025 | 6.44 × 10−04 | PPP2R2D (TSS1500; 5′UTR; First Exon; body) |
chr6:22,297,336-22,298,146 | 4 | 0.042 | 1.49 × 10−03 | PRL (TSS1500; 5′UTR; First Exon) |
chr7:158,669,801-158,669,978 | 5 | 0.019 | 1.90 × 10−03 | WDR60 (body) |
chr5:40,908,228-40,908,780 | 4 | 0.040 | 2.25 × 10−03 | C7 (TSS1500) |
chr5:132,200,008-132,200,666 | 6 | 0.016 | 2.27 × 10−03 | GDF9 (TSS200; First Exon) |
chr1:169,702,841-169,703,751 | 4 | 0.029 | 3.41 × 10− 03 | SELE (TSS1500; 5′UTR) |
chr7:95,114,680-95,115,354 | 8 | 0.024 | 4.84 × 10− 03 | ASB4 (TSS1500; First Exon) |
chr7:54,794,693-54,794,760 | 3 | 0.038 | 4.94 × 10−03 | – |
chr6:28,540,442-28,541,039 | 5 | 0.021 | 6.01 × 10−03 | SCAND3 (body) |
chr6:3,129,395-3,129,410 | 3 | 0.025 | 6.11 × 10−03 | BPHL (Body); SNORD6 (TSS200); SNORA32 (TSS1500); SNORA25 (TSS1500) |
chr6:125,623,465-125,623,573 | 3 | 0.035 | 6.28 × 10−03 | HDDC2 (TSS1500; TSS200) |
chr13:36,421,844-36,421,949 | 3 | 0.060 | 6.33 × 10−03 | MIR548F5 (body)/DCLK1 (body) |
chr20:39,666,232-39,666,765 | 3 | 0.042 | 6.55 × 10−03 | TOP1 (body)/PRO0628 (TSS1500; body) |
chr10:682,147-682,486 | 4 | 0.037 | 8.01 × 10−03 | DIP2C (body) |
chr19:46,999,055-46,999,118 | 3 | 0.039 | 8.13 × 10−03 | PNMAL2 (5′UTR; First Exon) |
chr3:75,263,619-75,263,641 | 3 | 0.039 | 9.35 × 10−03 | – |
chr19:55,889,013-55,889,387 | 4 | 0.032 | 0.011 | TMEM190 (body) |
chr15:28,272,345-28,272,656 | 3 | 0.019 | 0.012 | OCA2 (body) |
chr11:63,136,414-63,137,125 | 3 | 0.040 | 0.012 | SLC22A9 (TSS1500; TSS200) |
chr4:76,995,173-76,995,796 | 4 | 0.018 | 0,013 | ART3 (TSS1500; TSS200; 5′UTR) |