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Table 3 Results of DNA methylation and gene expression for the genes in which CpG sites were associated with the emergence of dimensional psychopathology

From: Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths

Gene DNA methylation GENE EXPRESSION
CpG annotation Gene annotation FDR β fold change Probe ID p value Log fold change
RASGRP1 chr15:38,781,997 3′UTR 0.049 0.041 2,760,239 0.002 − 0.285
BCL11A chr2:60,766,554 Body 0.043 0.069 6,580,450 0.005 −0.280
3,170,440 0.014 −0.232
ST13P4 chr13:50,745,306 TSS1500 0.045 0.046 4,050,195 0.007 −0.236
C7orf50 chr7:1,053,726 Body 0.043 0.112 5,810,671 0.008 0.206
WWP1 chr8:87,427,271 Body 0.045 0.041 1,980,201 0.009 −0.204
UBE3C chr7:156,951,457 Body 0.046 0.090 1,690,709 0.010 −0.156
RB1CC1 chr8:53,566,460 Body 0.045 0.086 3,890,092 0.012 −0.224
PUM1 chr1:31,486,063 Body < 0.001 0.066 3,870,543 0.022 −0.162
SMC3 chr10:112,331,306 Body 0.047 0.059 2,970,292 0.024 −0.187
RPS24 chr10:79,793,501 TSS200 0.046 − 0.014 830,066 0.025 −0.593
RPS6KB1 chr17:57,970,021 TSS1500 0.045 − 0.027 1,940,576 0.026 −0.194
KMT2E chr7:104,696,669 Body 0.045 0.050 3,120,050 0.033 0.249
FAM217B chr20:58,520,201 3′UTR 0.044 0.024 770,221 0.039 0.228
NIN chr14:51,295,867 5′UTR 0.043 0.078 5,310,717 0.043 −0.150
HNRNPM chr19:8,513,923 Body 0.043 0.073 2,360,669 0.045 −0.150
  1. Differentially methylated positions (DMPs) associated with the emergence of dimensional psychopathology in youths that had gene expression in peripheral venous blood identified by a HumanHT-12 v4.0 Expression BeadChip (Illumina). Probe location and gene annotation were taken from Illumina reference files. Annotation was performed according to hg19. Wave 0 (baseline) was used as the reference for both the DNA methylation and gene expression analyses. Probe ID unique identifier from the gene expression Illumina database. TSS200 0–200 bases upstream of the transcriptional start site (TSS). TSS1500 200–1500 bases upstream of the TSS. Official full names of the genes mentioned in the text: BCL11A B cell CLL/lymphoma 11A, KMT2E lysine methyltransferase 2E, RB1CC1 RB1 inducible coiled-coil 1, FAM217B family with sequence similarity 217 member B