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Table 3 Results of DNA methylation and gene expression for the genes in which CpG sites were associated with the emergence of dimensional psychopathology

From: Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths

Gene

DNA methylation

GENE EXPRESSION

CpG annotation

Gene annotation

FDR

β fold change

Probe ID

p value

Log fold change

RASGRP1

chr15:38,781,997

3′UTR

0.049

0.041

2,760,239

0.002

− 0.285

BCL11A

chr2:60,766,554

Body

0.043

0.069

6,580,450

0.005

−0.280

3,170,440

0.014

−0.232

ST13P4

chr13:50,745,306

TSS1500

0.045

0.046

4,050,195

0.007

−0.236

C7orf50

chr7:1,053,726

Body

0.043

0.112

5,810,671

0.008

0.206

WWP1

chr8:87,427,271

Body

0.045

0.041

1,980,201

0.009

−0.204

UBE3C

chr7:156,951,457

Body

0.046

0.090

1,690,709

0.010

−0.156

RB1CC1

chr8:53,566,460

Body

0.045

0.086

3,890,092

0.012

−0.224

PUM1

chr1:31,486,063

Body

< 0.001

0.066

3,870,543

0.022

−0.162

SMC3

chr10:112,331,306

Body

0.047

0.059

2,970,292

0.024

−0.187

RPS24

chr10:79,793,501

TSS200

0.046

− 0.014

830,066

0.025

−0.593

RPS6KB1

chr17:57,970,021

TSS1500

0.045

− 0.027

1,940,576

0.026

−0.194

KMT2E

chr7:104,696,669

Body

0.045

0.050

3,120,050

0.033

0.249

FAM217B

chr20:58,520,201

3′UTR

0.044

0.024

770,221

0.039

0.228

NIN

chr14:51,295,867

5′UTR

0.043

0.078

5,310,717

0.043

−0.150

HNRNPM

chr19:8,513,923

Body

0.043

0.073

2,360,669

0.045

−0.150

  1. Differentially methylated positions (DMPs) associated with the emergence of dimensional psychopathology in youths that had gene expression in peripheral venous blood identified by a HumanHT-12 v4.0 Expression BeadChip (Illumina). Probe location and gene annotation were taken from Illumina reference files. Annotation was performed according to hg19. Wave 0 (baseline) was used as the reference for both the DNA methylation and gene expression analyses. Probe ID unique identifier from the gene expression Illumina database. TSS200 0–200 bases upstream of the transcriptional start site (TSS). TSS1500 200–1500 bases upstream of the TSS. Official full names of the genes mentioned in the text: BCL11A B cell CLL/lymphoma 11A, KMT2E lysine methyltransferase 2E, RB1CC1 RB1 inducible coiled-coil 1, FAM217B family with sequence similarity 217 member B
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Clinical Epigenetics

ISSN: 1868-7083

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