From: Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation
Event-free survival
Multivariate analysis
Variables
HR
95% CI
P
H3K27me3 HIST1high
1.76
1.04–2.99
0.036
Age > 60 years
0.60
0.36–0.99
0.044
FLT3ITD/DNMT3 mut
0.48
0.27–0.83
0.009