Skip to main content

Advertisement

Table 1 Clinical and molecular characteristics according to H3K27me3 HIST1 level in the NPM1mut AML cohort

From: Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

Characteristics All patients (n = 103) H3K27me3 HIST1low (n = 28) H3K27me3 HIST1high (n = 75) P
Age, years     0.42
 Median 61 62 60  
 Range 22–76 37–76 22–76  
Sex, %     1.0
 Male 43 42.8 44  
WBC, × 10e9/L 67 87.9 55.6 0.57
 Median 67 87.9 55.6  
 Range 10–352 10–352 11–230  
Complete response, % 94 88.4 96.0 0.18
Allo-HSCT in 1st CR, % 23 32.1 20.0 0.2
FAB classification,%     1.0
 0–2 51.8 50.0 52.6  
 4–5 48.2 50.0 47.4  
CD34 expressiona     0.005
 Mean 15.3 35.0 10.3  
 Range 0–99 12–99 0–93  
Molecular alterations, %     
FLT3ITD 47.0 37.0 50.6 0.36
DNMT3Ab 50.5 57.6 43.1 0.25
FLT3ITD/DNMT3Ab 23.1 23.1 23.1 1.0
IDH2 (R140)b 21.9 7.6 27.6 0.05
IDH1 (R132)b 12.1 15.3 10.7 0.72
CEBPAb 5.4 7.6 4.6 0.62
ASXL1b 3.2 3.8 3.1 1.0
  1. Allo HSCT allogenic stem-cell transplantation, CR complete response, WBC white blood cell
  2. aN = 72
  3. bN = 91