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Table 1 Clinical and molecular characteristics according to H3K27me3 HIST1 level in the NPM1mut AML cohort

From: Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

Characteristics

All patients (n = 103)

H3K27me3 HIST1low (n = 28)

H3K27me3 HIST1high (n = 75)

P

Age, years

   

0.42

 Median

61

62

60

 

 Range

22–76

37–76

22–76

 

Sex, %

   

1.0

 Male

43

42.8

44

 

WBC, × 10e9/L

67

87.9

55.6

0.57

 Median

67

87.9

55.6

 

 Range

10–352

10–352

11–230

 

Complete response, %

94

88.4

96.0

0.18

Allo-HSCT in 1st CR, %

23

32.1

20.0

0.2

FAB classification,%

   

1.0

 0–2

51.8

50.0

52.6

 

 4–5

48.2

50.0

47.4

 

CD34 expressiona

   

0.005

 Mean

15.3

35.0

10.3

 

 Range

0–99

12–99

0–93

 

Molecular alterations, %

    

FLT3ITD

47.0

37.0

50.6

0.36

DNMT3Ab

50.5

57.6

43.1

0.25

FLT3ITD/DNMT3Ab

23.1

23.1

23.1

1.0

IDH2 (R140)b

21.9

7.6

27.6

0.05

IDH1 (R132)b

12.1

15.3

10.7

0.72

CEBPAb

5.4

7.6

4.6

0.62

ASXL1b

3.2

3.8

3.1

1.0

  1. Allo HSCT allogenic stem-cell transplantation, CR complete response, WBC white blood cell
  2. aN = 72
  3. bN = 91