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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

Fig. 3

Gene expression from the HIST1 cluster impacts on survival in NPM1mut CN-AML. a mRNA analyses of HIST1 genes in the IPC cohort of NPM1mut CN-AML patients. HIST1H1D (n = 46), HIST1H2BH (n = 45), and HIST1H2BG (n = 47) mRNA levels were determined by Taqman, according to H3K27me3 HIST1 status. Gene expression was normalized on the average of two housekeeping genes (PGK1 and PPIA). Statistical significance was estimated using Mann Whitney test * p < 0.05; **p < 0.005 ***p < 0.0001. b Influence of histone gene expression on OS by univariate analysis. Only histone genes covered by the H3K27me3 HIST1 mark described in [10] were analyzed. c Survival analyzed according to the expression of HIST1H1D, HIST1H2BG, and HIST1H2BH mRNA on independent cohorts of patients (TGCA and Metzeler). Patients were split into two groups according to the expression of HIST1H1D, HIST1H2BH and HIST1H2BG genes using a Cox regression prognosis model. Statistical significance was estimated using the log-rank test

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