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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of d-serine within the mouse cerebellum

Fig. 5

Epiallelic distribution profiling of the Dao gene during brain development in HIPP, CX, and CB. a Principal component analysis (PCA) plots show the epigenetic correlations of the Dao epiallele distribution during development in HIPP, CX, and CB. The score plots and loading plots of each PCA plot are merged to obtain biplots. The biplots are derived from the qualitative and quantitative influence of each of the 16 epialleles (indicated as a string of 1 s and 0 s) displayed by the three mice at P1 (red), P15 (blue), P30 (yellow), and P60 (green) in each analyzed brain area. The direction and length of the vectors (black lines) indicate how each epiallele and its abundance influence the sample position in the plot. Adjacent samples share similar epiallelic composition. Principal components 1 and 2 are reported for each brain area. b The overall PCA analysis of brain region differences based on the epiallelic composition is shown, including all developmental stages. On the left, the score plot displays the epigenetic correlation of Dao epialleles between HIPP (green), CX (blue), and CB (red). On the right, the loading plot of the PCA displays the impact of each of 16 Dao epialleles on the brain area distribution

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