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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Selective demethylation of two CpG sites causes postnatal activation of the Dao gene and consequent removal of d-serine within the mouse cerebellum

Fig. 1

d-Ser and d-Asp contents in the mouse hippocampus, cortex, and cerebellum during postnatal ontogenesis. Average ratio (expressed as %) of d-Ser/total Ser at different postnatal stages (P1, P15, P30, and P60) of C57BL/6 J mice in the a hippocampus (n = 4 P1, n = 3 P15/ P30/ P60), b cortex (n = 4 P1, n = 3 P15, n = 2 P30/ P60), and c cerebellum (n = 4 P1; n = 3 P15/P30/P60). Average ratio (expressed as %) of d-Asp/total Asp at different postnatal stages (P1, P15, P30, and P60) of C57BL/6 J mice in the d hippocampus (n = 4 P1, n = 3 P15/ P30/ P60), e cortex (n = 4 P1, n = 3 P15, n = 2 P30/ P60), and f cerebellum (n = 4 P1; n = 3 P15/ P30/P60). The d- and l-forms of Asp and Ser were quantified by HPLC analysis. *p < 0.05, **p < 0.01, ***p < 0.0001, compared with P1 (Fisher’s post hoc). Data are expressed as the mean ± SEM

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