Clinical Epigenetics

Table 2 Genetic risk load for Alzheimer’s disease in the Finnish twin pairs and unrelated individuals

From: Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

				Minor allele frequencies
SNP	Minor/major allele	Closest gene	Log-OR (p ≤ 1.0×10⁻⁴)^a	Meta-analysis^a	MZ twin pairs (n = 9)	DZ twin controls (n = 12)	DZ twin cases (n = 12)	Unrelated controls (n = 9)	Unrelated cases (n = 18)	All (n = 62)
rs10498633	G/T	SLC24A4-RIN3	− 0.094	0.22	0.22	0.21	0.17	0.17	0.17	0.18
rs10792832	G/A	PICALM	− 0.140	0.36	0.44	0.5	0.58	0.39	0.42	0.47
rs10838725	T/C	CELF1	0.079	0.32	0.28	0.29	0.29	0.33	0.31	0.3
rs10948363	A/G	CD2AP	0.095	0.27	0.22	0.08	0	0.22	0.11	0.12
rs11218343	T/C	SORL1	− 0.262	0.04	0.00	0	0	0	0	0
rs11771145	G/A	EPHA1	− 0.102	0.34	0.28	0.42	0.42	0.33	0.22	0.32
rs1476679	T/C	ZCWPW1	− 0.089	0.29	0.44	0.33	0.37	0.33	0.39	0.37
rs17125944	T/C	FERMT2	0.132	0.09	0.11	0.08	0.17	0.22	0.11	0.13
rs190982	A/G	MEF2C	− 0.076	0.41	0.44	0.33	0.29	0.33	0.28	0.32
rs2718058	A/G	NME8	− 0.077	0.37	0.33	0.17	0.29	0.44	0.19	0.27
rs28834970	T/C	PTK2B	0.100	0.37	0.44	0.29	0.21	0.39	0.31	0.32
rs35349669	C/T	INPP5D	0.076	0.49	0.50	0.58	0.62	0.11	0.53	0.49
rs3865444	C/A	CD33	− 0.067	0.31	0.11	0.42	0.33	0.33	0.36	0.32
rs4147929	G/A	ABCA7	0.143	0.19	0.06	0.17	0.12	0.11	0.14	0.12
rs6656401	G/A	CR1	0.167	0.20	0.22	0.42	0.33	0.33	0.22	0.3
rs6733839	C/T	BIN1	0.197	0.41	0.33	0.54	0.37	0.56	0.36	0.42
rs7274581	T/C	CASS4	− 0.132	0.08	0	0	0	0	0	0
rs8093731	C/T	DSG2	− 0.316	0.02	0	0	0	0	0	0
rs9271192	A/C	HLA-DRB5/-DRB1	0.108	0.28	0.33	0.29	0.42	0.33	0.56	0.41
rs9331896	T/C	CLU	− 0.146	0.38	0.22	0.58	0.42	0.28	0.5	0.42
rs983392 GRS^b	A/G	MS4A6A	− 0.108	0.40	0.39 − 0.16	0.42 − 0.27	0.33 − 0.39	0.61 − 0.28	0.39 − 0.03	0.42 − 0.36

^aFrom Lambert et al.
^bMedian standardized genetic risk score

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