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Table 2 Genetic risk load for Alzheimer’s disease in the Finnish twin pairs and unrelated individuals

From: Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

  Minor allele frequencies
SNP Minor/major allele Closest gene Log-OR (p ≤ 1.0×10−4)a Meta-analysisa MZ twin pairs (n = 9) DZ twin controls (n = 12) DZ twin cases (n = 12) Unrelated controls (n = 9) Unrelated cases (n = 18) All (n = 62)
rs10498633 G/T SLC24A4-RIN3 − 0.094 0.22 0.22 0.21 0.17 0.17 0.17 0.18
rs10792832 G/A PICALM − 0.140 0.36 0.44 0.5 0.58 0.39 0.42 0.47
rs10838725 T/C CELF1 0.079 0.32 0.28 0.29 0.29 0.33 0.31 0.3
rs10948363 A/G CD2AP 0.095 0.27 0.22 0.08 0 0.22 0.11 0.12
rs11218343 T/C SORL1 − 0.262 0.04 0.00 0 0 0 0 0
rs11771145 G/A EPHA1 − 0.102 0.34 0.28 0.42 0.42 0.33 0.22 0.32
rs1476679 T/C ZCWPW1 − 0.089 0.29 0.44 0.33 0.37 0.33 0.39 0.37
rs17125944 T/C FERMT2 0.132 0.09 0.11 0.08 0.17 0.22 0.11 0.13
rs190982 A/G MEF2C − 0.076 0.41 0.44 0.33 0.29 0.33 0.28 0.32
rs2718058 A/G NME8 − 0.077 0.37 0.33 0.17 0.29 0.44 0.19 0.27
rs28834970 T/C PTK2B 0.100 0.37 0.44 0.29 0.21 0.39 0.31 0.32
rs35349669 C/T INPP5D 0.076 0.49 0.50 0.58 0.62 0.11 0.53 0.49
rs3865444 C/A CD33 − 0.067 0.31 0.11 0.42 0.33 0.33 0.36 0.32
rs4147929 G/A ABCA7 0.143 0.19 0.06 0.17 0.12 0.11 0.14 0.12
rs6656401 G/A CR1 0.167 0.20 0.22 0.42 0.33 0.33 0.22 0.3
rs6733839 C/T BIN1 0.197 0.41 0.33 0.54 0.37 0.56 0.36 0.42
rs7274581 T/C CASS4 − 0.132 0.08 0 0 0 0 0 0
rs8093731 C/T DSG2 − 0.316 0.02 0 0 0 0 0 0
rs9271192 A/C HLA-DRB5/-DRB1 0.108 0.28 0.33 0.29 0.42 0.33 0.56 0.41
rs9331896 T/C CLU − 0.146 0.38 0.22 0.58 0.42 0.28 0.5 0.42
rs983392
GRSb
A/G MS4A6A − 0.108 0.40 0.39
− 0.16
0.42
− 0.27
0.33
− 0.39
0.61
− 0.28
0.39
− 0.03
0.42
− 0.36
  1. aFrom Lambert et al.
  2. bMedian standardized genetic risk score