From: Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease
Controls | Cases | ||||
---|---|---|---|---|---|
Study and sample type | No of subjects (male/female) | Age range (years) | No of subjects (male/female) | Age range (years) | |
Finnish cohort (n = 97) | |||||
Peripheral blood (n = 93) | |||||
ADDa MZ twin pairs | 12/9 | 67–86 | 12/9 | 67–86 | |
ADD DZ twin pairs | 6/6 | 70–72 | 6/6 | 70–72 | |
Unrelated individuals | 1/8 | 61–77 | 9/9 | 70–86 | |
Peripheral blood mononuclear cells (n = 4) | |||||
MZ twin pairs discordant for episodic memory | 2/0 | 76 | 2/0 | 76 | |
Swedish cohort (n = 298) | |||||
Peripheral blood (n = 298) | |||||
ADD MZ twin pairs | 5/5 | 62–83 | 5/5 | 63-83 | |
ADD DZ twin pairs | 11/8 | 63–84 | 11/8 | 63–84 | |
Incidentb ADD MZ twin pairs | 15/23 | 62–85 | 15/23 | 62–85 | |
Incident ADD DZ twin pairs | 33/49 | 53–88 | 33/49 | 53–88 | |
NIH NeuroBioBank (n = 12) | |||||
Anterior hippocampus with entorhinal cortex (n = 12) | |||||
Unrelated individuals | 4/2 | 56–89 | 4/2 | 57–90 | |
Total (n = 407) | 89/110 | 53–90 | 97/111 | 53–90 |