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Table 1 Characteristics of the samples utilized in the study

From: Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

 

Controls

Cases

Study and sample type

No of subjects (male/female)

Age range (years)

No of subjects (male/female)

Age range (years)

Finnish cohort (n = 97)

 Peripheral blood (n = 93)

  ADDa MZ twin pairs

12/9

67–86

12/9

67–86

  ADD DZ twin pairs

6/6

70–72

6/6

70–72

  Unrelated individuals

1/8

61–77

9/9

70–86

 Peripheral blood mononuclear cells (n = 4)

  MZ twin pairs discordant for episodic memory

2/0

76

2/0

76

Swedish cohort (n = 298)

 Peripheral blood (n = 298)

  ADD MZ twin pairs

5/5

62–83

5/5

63-83

  ADD DZ twin pairs

11/8

63–84

11/8

63–84

  Incidentb ADD MZ twin pairs

15/23

62–85

15/23

62–85

  Incident ADD DZ twin pairs

33/49

53–88

33/49

53–88

NIH NeuroBioBank (n = 12)

 Anterior hippocampus with entorhinal cortex (n = 12)

  Unrelated individuals

4/2

56–89

 

4/2

57–90

Total (n = 407)

89/110

53–90

 

97/111

53–90

  1. aAlzheimer’s disease-discordant
  2. bSample collected 0.5–18.5 years before disease onset