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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Peripheral blood DNA methylation differences in twin pairs discordant for Alzheimer’s disease

Fig. 1

Peripheral blood CpG methylation differences in Finnish twin pairs discordant for Alzheimer’s disease. Peripheral blood CpG methylomes of 11 monozygotic (MZ) and 12 dizygotic (DZ) Finnish twin pairs discordant for Alzheimer’s disease (AD) were profiled with reduced representation bisulfite sequencing. Differentially methylated sites associated with AD in autosomes were identified using RADMeth algorithm and ± 15.0% average methylation difference and B-H FDR adjusted p value cut off 0.05 in a MZ and b DZ twin pairs separately. c Differentially methylated sites detected in both MZ and DZ twin pairs were extracted to identify overlaps between the AD-associated sites detected in both groups (Additional file 2). d Combined median methylation difference and adjusted p value (adj. pval) distribution of these 11 regions associated with AD in both MZ and DZ twin pairs is illustrated. The size of the dot indicates the percentage of the twin pairs, which had the required ≥ 10× coverage in the region. The closest or overlapping gene is indicated for the selected differentially methylated regions

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