Table 1 List of cfDNA methylation aggregate biomarkers with high sensitivity for chronic pancreatitis or pancreatic cancer diagnosis
From: Deciphering DNA methylation signatures of pancreatic cancer and pancreatitis
Aggregate biomarkers | Comparison | Diagnostic method | Test performance (95% CI) | Reference | ||
|---|---|---|---|---|---|---|
Combined sensitivity | Combined specificity | |||||
CLDN5 | NPTX2 | CP vs. PT | MSP | 75% | 75% | Sato et al. 2003a [59] |
SFRP1 | ||||||
CCND2 | FOXE1 | N + CP vs. PT | qMSP | 82% | 100% | Matsubayashi et al. 2006 [76] |
NPTX2 | PENK | |||||
TFPI2 | ||||||
CCND2 | PLAU | N vs. PT | MCAM | 76% | 59% | Melnikov et al. 2009 [77] |
SOCS1 | THBS1 | |||||
VHL | ||||||
BRCA1 | CCND2 | N vs. CP | MCAM | 82% | 78% | Ligget et al. 2010 [80] |
CDKN1C | MLH1 | |||||
PGR (distal) | PGR (proximal) | |||||
SYK | VHL | |||||
CDKN1C | CDKN1B | CP vs. PT | MCAM | 91% | 91% | Ligget et al. 2010 [80] |
CCND2 | DAPK1 | |||||
ESR1(A) | MGMT | |||||
MLH1 | MUC2 | |||||
MYOD1 | PGK1 | |||||
PGR (proximal) | RARB | |||||
RB1 | SYK | |||||
ADAMTS1 | BNC1 | N vs. PT | qPCR | 81% (69%–93%) | 85% (71%–99%) | Yi et al. 2013 [65] |
APC | BMP3 | CP vs. PT | MSP | 76% | 83% | Henriksen et al. 2016 [82] |
BNC1 | MESTv2 | |||||
RASSF1A | SFRP1 | |||||
SFRP2 | TFPI2 | |||||
Age (> 65) | ||||||