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Table 1 List of cfDNA methylation aggregate biomarkers with high sensitivity for chronic pancreatitis or pancreatic cancer diagnosis

From: Deciphering DNA methylation signatures of pancreatic cancer and pancreatitis

Aggregate biomarkers Comparison Diagnostic method Test performance (95% CI) Reference
Combined sensitivity Combined specificity
CLDN5 NPTX2 CP vs. PT MSP 75% 75% Sato et al. 2003a [59]
SFRP1  
CCND2 FOXE1 N + CP vs. PT qMSP 82% 100% Matsubayashi et al. 2006 [76]
NPTX2 PENK
TFPI2  
CCND2 PLAU N vs. PT MCAM 76% 59% Melnikov et al. 2009 [77]
SOCS1 THBS1
VHL  
BRCA1 CCND2 N vs. CP MCAM 82% 78% Ligget et al. 2010 [80]
CDKN1C MLH1
PGR (distal) PGR (proximal)
SYK VHL
CDKN1C CDKN1B CP vs. PT MCAM 91% 91% Ligget et al. 2010 [80]
CCND2 DAPK1
ESR1(A) MGMT
MLH1 MUC2
MYOD1 PGK1
PGR (proximal) RARB
RB1 SYK
ADAMTS1 BNC1 N vs. PT qPCR 81% (69%–93%) 85% (71%–99%) Yi et al. 2013 [65]
APC BMP3 CP vs. PT MSP 76% 83% Henriksen et al. 2016 [82]
BNC1 MESTv2
RASSF1A SFRP1
SFRP2 TFPI2
Age (> 65)  
  1. CP chronic pancreatitis, PT pancreatic adenocarcinoma, N normal. The gene names’ was included in gene names’ abbreviation section